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HPSE heparanase [ Homo sapiens (human) ]

Gene ID: 10855, updated on 3-Jun-2018
Official Symbol
HPSEprovided by HGNC
Official Full Name
heparanaseprovided by HGNC
Primary source
HGNC:HGNC:5164
See related
Ensembl:ENSG00000173083 MIM:604724; Vega:OTTHUMG00000130425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPA; HPA1; HPR1; HSE1; HPSE1
Summary
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in appendix (RPKM 3.0), esophagus (RPKM 2.9) and 24 other tissues See more
Orthologs
See HPSE in Genome Data Viewer
Location:
4q21.23
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (83292461..83335153, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (84213614..84256306, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene placenta specific 8 Neighboring gene coenzyme Q2, polyprenyltransferase Neighboring gene aminomethyltransferase pseudogene Neighboring gene uncharacterized LOC105377313 Neighboring gene chromosome 18 open reading frame 21 pseudogene Neighboring gene helicase, POLQ like Neighboring gene mitochondrial ribosomal protein S18C

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment of synaptosomes with heparanase and HIV-1 Tat increases Tat-induced oxidative stress, which indicates the requirement of Tat interaction with neuronal membranes to induce oxidative damage PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-glucuronidase activity TAS
Traceable Author Statement
more info
PubMed 
heparanase activity IDA
Inferred from Direct Assay
more info
PubMed 
heparanase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
syndecan binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
angiogenesis involved in wound healing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
glycosaminoglycan catabolic process TAS
Traceable Author Statement
more info
 
heparan sulfate proteoglycan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of hair follicle development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vascular endothelial growth factor production IDA
Inferred from Direct Assay
more info
PubMed 
proteoglycan metabolic process TAS
Traceable Author Statement
more info
PubMed 
regulation of hair follicle development IDA
Inferred from Direct Assay
more info
PubMed 
vascular wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosomal lumen TAS
Traceable Author Statement
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
specific granule lumen TAS
Traceable Author Statement
more info
 
Preferred Names
heparanase
Names
endo-glucoronidase
heparanase-1
NP_001092010.1
NP_001159970.1
NP_001186759.1
NP_006656.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028037.1 RefSeqGene

    Range
    5001..47693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001098540.2NP_001092010.1  heparanase isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001092010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC114781, AF144325, AF152376, AW293069
    Consensus CDS
    CCDS3602.1
    UniProtKB/Swiss-Prot
    Q9Y251
    Related
    ENSP00000308107.5, OTTHUMP00000160980, ENST00000311412.9, OTTHUMT00000252813
    Conserved Domains (1) summary
    pfam03662
    Location:171370
    Glyco_hydro_79n; Glycosyl hydrolase family 79, N-terminal domain
  2. NM_001166498.2NP_001159970.1  heparanase isoform 2 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the identical N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC114781, AF152376, AW293069, GQ337901
    Consensus CDS
    CCDS54774.1
    UniProtKB/Swiss-Prot
    Q9Y251
    Related
    ENSP00000423265.1, OTTHUMP00000219801, ENST00000512196.5, OTTHUMT00000363969
    Conserved Domains (1) summary
    pfam03662
    Location:171330
    Glyco_hydro_79n; Glycosyl hydrolase family 79, N-terminal domain
  3. NM_001199830.1NP_001186759.1  heparanase isoform 3 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the identical N- and C- termini compared to isoform 1.
    Source sequence(s)
    AC114781, AM419200, AW293069
    Consensus CDS
    CCDS56337.1
    UniProtKB/Swiss-Prot
    Q9Y251
    Related
    ENSP00000421365.1, OTTHUMP00000219799, ENST00000513463.1, OTTHUMT00000363967
    Conserved Domains (1) summary
    pfam03662
    Location:179312
    Glyco_hydro_79n; Glycosyl hydrolase family 79, N-terminal domain
  4. NM_006665.5NP_006656.2  heparanase isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_006656.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC114781, AF152376, AW293069, BC051321
    Consensus CDS
    CCDS3602.1
    UniProtKB/Swiss-Prot
    Q9Y251
    Related
    ENSP00000384262.2, OTTHUMP00000160979, ENST00000405413.6, OTTHUMT00000252812
    Conserved Domains (1) summary
    pfam03662
    Location:171370
    Glyco_hydro_79n; Glycosyl hydrolase family 79, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    83292461..83335153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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