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Hebp1r2 Hebp1R2 erythroid cis-regulatory module [ Mus musculus (house mouse) ]

Gene ID: 108511956, updated on 8-Feb-2024

Summary

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Gene symbol
Hebp1r2
Gene description
Hebp1R2 erythroid cis-regulatory module
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr366719
Summary
This genomic element is located in a 5' intron of the Hebp1 (heme binding protein 1) gene on chromosome 6. It was predicted to be a cis-regulatory module (preCRM) based on conservation of consensus binding motifs for the essential erythroid transcription factor GATA1, and on distinctive alignment patterns that yielded a positive regulatory potential score. It was validated as a functional enhancer by reporter assays in stably transfected murine erythroleukemia (MEL) cells. [provided by RefSeq, Aug 2016]
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Genomic context

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Location:
6 G1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (135142653..135142926)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135165655..135165928)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17563 Neighboring gene fucose mutarotase-like Neighboring gene heme binding protein 1 Neighboring gene Hebp1R3 erythroid cis-regulatory module Neighboring gene predicted gene, 22881 Neighboring gene predicted gene, 34391 Neighboring gene predicted gene, 19434 Neighboring gene predicted gene, 36533

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Experimental validation of predicted mammalian erythroid cis-regulatory modules. Wang H, et al. Genome Res, 2006 Dec. PMID 17038566, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Other Names

  • Hebp1R2 erythroid enhancer
  • Hebp1R2 preCRM
  • regulatory region 366719

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051408.1 

    Range
    101..374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    135142653..135142926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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