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CD3EAP CD3e molecule associated protein [ Homo sapiens (human) ]

Gene ID: 10849, updated on 9-Feb-2020

Summary

Official Symbol
CD3EAPprovided by HGNC
Official Full Name
CD3e molecule associated proteinprovided by HGNC
Primary source
HGNC:HGNC:24219
See related
Ensembl:ENSG00000117877 MIM:107325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASE1; CAST; ASE-1; PAF49; RPA34
Expression
Ubiquitous expression in skin (RPKM 8.1), ovary (RPKM 5.0) and 25 other tissues See more
Orthologs

Genomic context

See CD3EAP in Genome Data Viewer
Location:
19q13.32
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45406644..45410766)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45909467..45914024)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kinesin light chain 3 Neighboring gene ERCC excision repair 2, TFIIH core complex helicase subunit Neighboring gene protein phosphatase 1 regulatory subunit 13 like Neighboring gene ERCC excision repair 1, endonuclease non-catalytic subunit Neighboring gene Sharpr-MPRA regulatory region 13779 Neighboring gene microRNA 6088

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118851

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase I transcription factor complex TAS
Traceable Author Statement
more info
PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleolus TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase I subunit RPA34
Names
CD3e antigen, epsilon polypeptide associated protein
CD3e molecule, epsilon associated protein
RNA polymerase I-associated factor PAF49
antisense to ERCC-1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297590.2NP_001284519.1  DNA-directed RNA polymerase I subunit RPA34 isoform 1

    See identical proteins and their annotated locations for NP_001284519.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF017633, BU166593, U86751
    Consensus CDS
    CCDS74397.1
    UniProtKB/Swiss-Prot
    O15446
    Related
    ENSP00000465099.1, ENST00000589804.1
    Conserved Domains (1) summary
    pfam08208
    Location:40180
    RNA_polI_A34; DNA-directed RNA polymerase I subunit RPA34.5
  2. NM_012099.2NP_036231.1  DNA-directed RNA polymerase I subunit RPA34 isoform 2

    See identical proteins and their annotated locations for NP_036231.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    U86751
    Consensus CDS
    CCDS12661.1
    UniProtKB/Swiss-Prot
    O15446
    Related
    ENSP00000310966.3, ENST00000309424.7
    Conserved Domains (1) summary
    pfam08208
    Location:38178
    RNA_polI_A34; DNA-directed RNA polymerase I subunit RPA34.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45406644..45410766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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