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CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit X [ Homo sapiens (human) ]

Gene ID: 10845, updated on 3-May-2020

Summary

Official Symbol
CLPXprovided by HGNC
Official Full Name
caseinolytic mitochondrial matrix peptidase chaperone subunit Xprovided by HGNC
Primary source
HGNC:HGNC:2088
See related
Ensembl:ENSG00000166855 MIM:615611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPP2
Summary
The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in liver (RPKM 13.6), testis (RPKM 11.0) and 25 other tissues See more
Orthologs

Genomic context

See CLPX in Genome Data Viewer
Location:
15q22.31
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (65148219..65185374, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65442784..65477563, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ubiquitin associated protein 1 like Neighboring gene programmed cell death 7 Neighboring gene Sharpr-MPRA regulatory region 15221 Neighboring gene uncharacterized LOC112268147 Neighboring gene cartilage intermediate layer protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to ATP-dependent peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peptidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ATP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein folding IEA
Inferred from Electronic Annotation
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis involved in cellular protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
endopeptidase Clp complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial endopeptidase Clp complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
Names
ClpX caseinolytic peptidase X homolog
ClpX caseinolytic protease X homolog
energy-dependent regulator of proteolysis

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006660.5NP_006651.2  ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor

    See identical proteins and their annotated locations for NP_006651.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AC013553, AJ006267, BG717994, CA945006
    Consensus CDS
    CCDS10202.1
    UniProtKB/Swiss-Prot
    O76031
    UniProtKB/TrEMBL
    A0A024R5X7
    Related
    ENSP00000300107.3, ENST00000300107.7
    Conserved Domains (4) summary
    smart01086
    Location:509603
    ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
    TIGR00382
    Location:102600
    clpX; endopeptidase Clp ATP-binding regulatory subunit (clpX)
    pfam07724
    Location:286502
    AAA_2; AAA domain (Cdc48 subfamily)
    cl02609
    Location:104132
    Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

RNA

  1. NR_133680.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC013553, BC144166, BG717994, CA945006

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    65148219..65185374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521164.3XP_011519466.1  ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1

    Conserved Domains (4) summary
    smart01086
    Location:495589
    ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
    TIGR00382
    Location:102586
    clpX; endopeptidase Clp ATP-binding regulatory subunit (clpX)
    pfam07724
    Location:272488
    AAA_2; AAA domain (Cdc48 subfamily)
    cl02609
    Location:104132
    Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

RNA

  1. XR_931743.3 RNA Sequence

    Related
    ENST00000559152.5
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