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TUBGCP2 tubulin gamma complex associated protein 2 [ Homo sapiens (human) ]

Gene ID: 10844, updated on 23-Nov-2021

Summary

Official Symbol
TUBGCP2provided by HGNC
Official Full Name
tubulin gamma complex associated protein 2provided by HGNC
Primary source
HGNC:HGNC:18599
See related
Ensembl:ENSG00000130640 MIM:617817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALP4; GCP2; GCP-2; SPC97; h103p; hGCP2; SPBC97; Spc97p; hSpc97; Grip103; PAMDDFS
Expression
Ubiquitous expression in testis (RPKM 14.0), kidney (RPKM 12.2) and 25 other tissues See more
Orthologs
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Genomic context

See TUBGCP2 in Genome Data Viewer
Location:
10q26.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (133278635..133312337, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135092139..135125841, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MIR202 host gene Neighboring gene microRNA 202 Neighboring gene ADAM metallopeptidase domain 8 Neighboring gene ZNF511-PRAP1 readthrough Neighboring gene Sharpr-MPRA regulatory region 2011 Neighboring gene zinc finger protein 511 Neighboring gene calcyon neuron specific vesicular protein Neighboring gene BANF1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46573, MGC138162

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic microtubule TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in equatorial microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of gamma-tubulin small complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule organizing center IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
gamma-tubulin complex component 2
Names
gamma-ring complex protein 103 kDa
hGrip103
spindle pole body protein Spc97 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256617.2NP_001243546.1  gamma-tubulin complex component 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA377890, AL360181, AL592071, BC143247, CK818507
    Consensus CDS
    CCDS58105.1
    UniProtKB/Swiss-Prot
    Q9BSJ2
    Related
    ENSP00000446093.1, ENST00000543663.6
    Conserved Domains (2) summary
    pfam04130
    Location:537893
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:246534
    GCP_N_terminal; Gamma tubulin complex component N-terminal
  2. NM_001256618.2NP_001243547.1  gamma-tubulin complex component 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a downstream, in-frame start codon and lacks two exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AA377890, AK297251, AL592071
    Consensus CDS
    CCDS58104.1
    UniProtKB/Swiss-Prot
    Q9BSJ2
    Related
    ENSP00000395666.2, ENST00000417178.7
    Conserved Domains (1) summary
    pfam04130
    Location:90608
    Spc97_Spc98; Spc97 / Spc98 family
  3. NM_006659.4NP_006650.1  gamma-tubulin complex component 2 isoform 2

    See identical proteins and their annotated locations for NP_006650.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA377890, AF042379, AK223586, AL592071
    Consensus CDS
    CCDS7676.1
    UniProtKB/Swiss-Prot
    Q9BSJ2
    UniProtKB/TrEMBL
    Q53EQ3
    Related
    ENSP00000252936.3, ENST00000252936.8
    Conserved Domains (2) summary
    pfam04130
    Location:509865
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:218506
    GCP_N_terminal; Gamma tubulin complex component N-terminal

RNA

  1. NR_046330.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5'-most exon, lacks an internal exon and uses an alternate splice in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA377890, AK092113, AL592071
    Related
    ENST00000683786.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    133278635..133312337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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