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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_012260.2 RefSeqGene
- Range
-
22359..99375
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001270364.2 → NP_001257293.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform 1
See identical proteins and their annotated locations for NP_001257293.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
- Source sequence(s)
-
AC079848
- Consensus CDS
-
CCDS58851.1
- UniProtKB/TrEMBL
-
Q53H87
- Related
- ENSP00000273450.3, ENST00000273450.7
- Conserved Domains (5) summary
-
- cd07140
Location:427 → 912
- ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
- cd08647
Location:11 → 213
- FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
- cd08703
Location:216 → 316
- FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
- COG0223
Location:10 → 319
- Fmt; Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]
- pfam00550
Location:335 → 401
- PP-binding; Phosphopantetheine attachment site
-
NM_001270365.2 → NP_001257294.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the both the 5' UTR and the coding sequence, but maintains the reading frame, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
- Source sequence(s)
-
AC079848, AK222694, AK294392
- Consensus CDS
-
CCDS58850.1
- UniProtKB/TrEMBL
-
Q53H87
- Related
- ENSP00000395881.2, ENST00000452905.6
- Conserved Domains (4) summary
-
- cd07140
Location:316 → 801
- ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
- cd08703
Location:116 → 205
- FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
- pfam00550
Location:224 → 290
- PP-binding; Phosphopantetheine attachment site
- cl00395
Location:1 → 128
- FMT_core; Formyltransferase, catalytic core domain
-
NM_012190.4 → NP_036322.2 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform 2
See identical proteins and their annotated locations for NP_036322.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region, and initiates translation at an alternate in-frame downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
- Source sequence(s)
-
AC079848, AF052732, AK222694, DC342268
- Consensus CDS
-
CCDS3034.1
- UniProtKB/Swiss-Prot
- B4DG36, E9PBX3, O75891, Q68CS1, Q8TBP8
- UniProtKB/TrEMBL
-
Q53H87
- Related
- ENSP00000377083.3, ENST00000393434.7
- Conserved Domains (4) summary
-
- cd07140
Location:417 → 902
- ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
- cd08647
Location:1 → 203
- FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
- cd08703
Location:206 → 306
- FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
- pfam00550
Location:325 → 391
- PP-binding; Phosphopantetheine attachment site
RNA
-
NR_072979.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AK222694, BC027241, DC342268
- Related
-
ENST00000393431.6
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000003.12 Reference GRCh38.p14 Primary Assembly
- Range
-
126103570..126197945 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_024453325.2 → XP_024309093.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X1
- UniProtKB/Swiss-Prot
- B4DG36, E9PBX3, O75891, Q68CS1, Q8TBP8
- UniProtKB/TrEMBL
-
Q53H87
- Conserved Domains (4) summary
-
- cd07140
Location:417 → 902
- ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
- cd08647
Location:1 → 203
- FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
- cd08703
Location:206 → 306
- FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
- pfam00550
Location:325 → 391
- PP-binding; Phosphopantetheine attachment site
-
XM_011512355.2 → XP_011510657.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X1
See identical proteins and their annotated locations for XP_011510657.1
- UniProtKB/Swiss-Prot
- B4DG36, E9PBX3, O75891, Q68CS1, Q8TBP8
- UniProtKB/TrEMBL
-
Q53H87
- Related
- ENSP00000420293.1, ENST00000472186.5
- Conserved Domains (4) summary
-
- cd07140
Location:417 → 902
- ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
- cd08647
Location:1 → 203
- FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
- cd08703
Location:206 → 306
- FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
- pfam00550
Location:325 → 391
- PP-binding; Phosphopantetheine attachment site
-
XM_017005613.3 → XP_016861102.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X2
- UniProtKB/TrEMBL
-
Q53H87
-
XM_006713481.4 → XP_006713544.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X1
See identical proteins and their annotated locations for XP_006713544.1
- UniProtKB/Swiss-Prot
- B4DG36, E9PBX3, O75891, Q68CS1, Q8TBP8
- UniProtKB/TrEMBL
-
Q53H87
- Conserved Domains (4) summary
-
- cd07140
Location:417 → 902
- ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
- cd08647
Location:1 → 203
- FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
- cd08703
Location:206 → 306
- FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
- pfam00550
Location:325 → 391
- PP-binding; Phosphopantetheine attachment site
-
XM_017005614.3 → XP_016861103.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X3
- UniProtKB/TrEMBL
-
Q53H87
Alternate T2T-CHM13v2.0
Genomic
-
NC_060927.1 Alternate T2T-CHM13v2.0
- Range
-
128835963..128930120 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054345030.1 → XP_054201005.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X1
- UniProtKB/Swiss-Prot
- B4DG36, E9PBX3, O75891, Q68CS1, Q8TBP8
- UniProtKB/TrEMBL
-
Q53H87
-
XM_054345029.1 → XP_054201004.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X1
- UniProtKB/Swiss-Prot
- B4DG36, E9PBX3, O75891, Q68CS1, Q8TBP8
- UniProtKB/TrEMBL
-
Q53H87
-
XM_054345031.1 → XP_054201006.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X2
- UniProtKB/TrEMBL
-
Q53H87
-
XM_054345028.1 → XP_054201003.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X1
- UniProtKB/Swiss-Prot
- B4DG36, E9PBX3, O75891, Q68CS1, Q8TBP8
- UniProtKB/TrEMBL
-
Q53H87
-
XM_054345032.1 → XP_054201007.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X3
- UniProtKB/TrEMBL
-
Q53H87
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_144776.1: Suppressed sequence
- Description
- NM_144776.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.