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CEACAM3 CEA cell adhesion molecule 3 [ Homo sapiens (human) ]

Gene ID: 1084, updated on 7-Jun-2020

Summary

Official Symbol
CEACAM3provided by HGNC
Official Full Name
CEA cell adhesion molecule 3provided by HGNC
Primary source
HGNC:HGNC:1815
See related
Ensembl:ENSG00000170956 MIM:609142
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEA; CGM1; W264; W282; CD66D
Summary
This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
Expression
Biased expression in bone marrow (RPKM 11.7), appendix (RPKM 5.0) and 3 other tissues See more
Orthologs

Genomic context

See CEACAM3 in Genome Data Viewer
Location:
19q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41796587..41811554)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42300522..42315591)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule 5 Neighboring gene uncharacterized LOC112268252 Neighboring gene CEA cell adhesion molecule 6 Neighboring gene CEA cell adhesion molecule 1 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 52 Neighboring gene LY6/PLAUR domain containing 4 Neighboring gene DMRT like family C2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ51937, MGC119875

Gene Ontology Provided by GOA

Process Evidence Code Pubs
leukocyte migration TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 3
Names
CD66d antigen
carcinoembryonic antigen CGM1
carcinoembryonic antigen gene family member 1
carcinoembryonic antigen related cell adhesion molecule 3
nonspecific cross-reacting antigen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277163.3NP_001264092.1  carcinoembryonic antigen-related cell adhesion molecule 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001264092.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon and has an alternate splice site in the 3' region, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC243967, D90277, D90278, DC428993, L00693
    Consensus CDS
    CCDS62685.1
    UniProtKB/Swiss-Prot
    P40198
    Related
    ENSP00000341725.4, ENST00000344550.4
    Conserved Domains (1) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
  2. NM_001815.5NP_001806.2  carcinoembryonic antigen-related cell adhesion molecule 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001806.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC243967, BC106728, D90277, D90278, DC428993
    Consensus CDS
    CCDS12586.2
    UniProtKB/Swiss-Prot
    P40198
    Related
    ENSP00000349971.3, ENST00000357396.8
    Conserved Domains (1) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

RNA

  1. NR_102333.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC243967, D90277, D90278, DC428993
    Related
    ENST00000415495.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    41796587..41811554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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