CEACAM3 CEA cell adhesion molecule 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CEACAM3provided by HGNC
Official Full Name: CEA cell adhesion molecule 3provided by HGNC
Primary source: HGNC:HGNC:1815
See related: Ensembl:ENSG00000170956 MIM:609142
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CEA; CGM1; W264; W282; CD66D
Summary: This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
Expression: Biased expression in bone marrow (RPKM 11.7), appendix (RPKM 5.0) and 3 other tissues See more
Orthologs: all

Genomic context

Location:: 19q13.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109.20200522	current	GRCh38.p13 (GCF_000001405.39)	19	NC_000019.10 (41796587..41811554)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (42300522..42315591)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Amino acid alterations found in CEACAM3 translate into characteristic binding patterns for bacterial adhesins. One such amino acid residue is F62 in human and chimp CEACAM3, which is critical for binding the OMP P1 adhesin of Haemophilus aegyptius. Incorporation of the F62-containing motif into gorilla CEACAM3 results in a gain-of-function phenotype with regard to phagocytosis of H. aegyptius.
Title: Adaptation to Host-Specific Bacterial Pathogens Drives Rapid Evolution of a Human Innate Immune Receptor.
High serum CEA expression is associated with systemic recurrence in colorectal cancer.
Title: Serum carcinoembryonic antigen to predict recurrence in the follow-up of patients with colorectal cancer.
the findings reveal an integration of the specific innate immune receptor CEACAM3 into the network of more conventional pattern recognition receptors, providing a mechanism by which the innate immune system can unleash its response to a relentless pathogen.
Title: Bcl10 synergistically links CEACAM3 and TLR-dependent inflammatory signalling.
Here, the authors identify members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as receptors of Helicobacter pylori and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6.
Title: Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.
Helicobacter pylori HopQ binds the amino-terminal IgV-like domain of human CEACAM1, CEACAM3, CEACAM5 or CEACAM6 proteins, thereby enabling translocation of the major pathogenicity factor CagA into host cells.
Title: Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA.
CEACAM3 signalling in neutrophils is able to specifically modulate airway inflammation caused by infection with M. catarrhalis.
Title: Moraxella catarrhalis induces CEACAM3-Syk-CARD9-dependent activation of human granulocytes.
We demonstrate that recombinant Neisseria Opa proteins reconstituted into liposomes retain the ability to recognize and interact with CEACAM1 and 3 in vitro but do not maintain receptor specificity compared to that of Opa proteins natively expressed by Neisseria gonorrhoeae.
Title: Neisserial Opa Protein-CEACAM Interactions: Competition for Receptors as a Means of Bacterial Invasion and Pathogenesis.
Opacity protein OpaI of Neisseria gonorrhoeae in lipooligosaccharide mutants lost ability to interact with neutrophil-restricted CEACAM3.
Title: Opacity proteins of neisseria gonorrhoeae in lipooligosaccharide mutants lost ability to interact with neutrophil-restricted CEACAM3 (CD66d).
p-CEA measurement in patients with pleural effusion of uncertain etiology is a safe and cost-effective procedure, everywhere easily available, which may help clinicians in selecting patients for further evaluations
Title: Evaluation of predictive value of pleural CEA in patients with pleural effusions and histological findings: A prospective study and literature review.
Demonstrated the CEACAM3 specificity and a perioperative trend of circulating tumor cells which is coherent with the clinical/pathological considerations in colorectal cancer.
Title: The Trend of CEACAM3 Blood Expression as Number Index of the CTCs in the Colorectal Cancer Perioperative Course.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-148301 (e-PCR)
- UniSTS:176308

D19S1099 (e-PCR)
- UniSTS:47567

NoName (e-PCR)
- UniSTS:483827

STS-D90277 (e-PCR)
- UniSTS:70388

Homology

Orthologs from Annotation Pipeline: 14 organisms have orthologs with human gene CEACAM3
Orthologs

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
leukocyte migration	TAS Traceable Author Statement more info
neutrophil degranulation	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
integral component of membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info
specific granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: carcinoembryonic antigen-related cell adhesion molecule 3

Names: CD66d antigen; carcinoembryonic antigen CGM1; carcinoembryonic antigen gene family member 1; carcinoembryonic antigen related cell adhesion molecule 3; nonspecific cross-reacting antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277163.3 → NP_001264092.1 carcinoembryonic antigen-related cell adhesion molecule 3 isoform 2 precursor

See identical proteins and their annotated locations for NP_001264092.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate coding exon and has an alternate splice site in the 3' region, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC243967, D90277, D90278, DC428993, L00693

Consensus CDS

CCDS62685.1

UniProtKB/Swiss-Prot

P40198

Related

ENSP00000341725.4, ENST00000344550.4

Conserved Domains (1) summary

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
NM_001815.5 → NP_001806.2 carcinoembryonic antigen-related cell adhesion molecule 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_001806.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC243967, BC106728, D90277, D90278, DC428993

Consensus CDS

CCDS12586.2

UniProtKB/Swiss-Prot

P40198

Related

ENSP00000349971.3, ENST00000357396.8

Conserved Domains (1) summary

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

RNA

NR_102333.3 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an additional exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC243967, D90277, D90278, DC428993

Related

ENST00000415495.5