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CGB3 chorionic gonadotropin subunit beta 3 [ Homo sapiens (human) ]

Gene ID: 1082, updated on 7-Jun-2020

Summary

Official Symbol
CGB3provided by HGNC
Official Full Name
chorionic gonadotropin subunit beta 3provided by HGNC
Primary source
HGNC:HGNC:1886
See related
Ensembl:ENSG00000104827 MIM:118860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGB; CGB5; CGB7; CGB8; hCGB
Summary
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward placenta (RPKM 30.5) See more

Genomic context

See CGB3 in Genome Data Viewer
Location:
19q13.33
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49022869..49024375, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49526126..49527632, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RuvB like AAA ATPase 2 Neighboring gene uncharacterized LOC101059948 Neighboring gene luteinizing hormone subunit beta Neighboring gene neurotrophin 6 alpha (pseudogene) Neighboring gene neurotrophin 6 gamma (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
female gamete generation TAS
Traceable Author Statement
more info
PubMed 
hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone processing TAS
Traceable Author Statement
more info
 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
choriogonadotropin subunit beta 3
Names
CG-beta
chorionic gonadotrophin chain beta
chorionic gonadotropin beta 3 subunit
chorionic gonadotropin beta chain
chorionic gonadotropin beta subunit 3
chorionic gonadotropin chain beta
chorionic gonadotropin, beta polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000737.3NP_000728.1  choriogonadotropin subunit beta 3 precursor

    See identical proteins and their annotated locations for NP_000728.1

    Status: REVIEWED

    Source sequence(s)
    AK291552, BC106059, BX334905
    Consensus CDS
    CCDS12749.1
    UniProtKB/Swiss-Prot
    P0DN86
    UniProtKB/TrEMBL
    A0A0F7RQP8
    Related
    ENSP00000349954.2, ENST00000357383.4
    Conserved Domains (1) summary
    smart00068
    Location:25131
    GHB; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49022869..49024375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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