U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ubxn8 UBX domain protein 8 [ Mus musculus (house mouse) ]

Gene ID: 108159, updated on 11-Apr-2024

Summary

Official Symbol
Ubxn8provided by MGI
Official Full Name
UBX domain protein 8provided by MGI
Primary source
MGI:MGI:1337129
See related
Ensembl:ENSMUSG00000052906 AllianceGenome:MGI:1337129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rep-8; Rep8h; Ubxd6; D0H8S2298E
Summary
Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum; nucleolus; and nucleoplasm. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human UBXN8 (UBX domain protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 11.6), placenta adult (RPKM 3.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ubxn8 in Genome Data Viewer
Location:
8 A4; 8 20.65 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34109614..34135515, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33619586..33645476, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 1, related sequence 17 Neighboring gene STARR-seq mESC enhancer starr_21108 Neighboring gene testis expressed gene 15 meiosis and synapsis associated Neighboring gene STARR-seq mESC enhancer starr_21109 Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform Neighboring gene STARR-positive B cell enhancer ABC_E4996 Neighboring gene STARR-seq mESC enhancer starr_21112 Neighboring gene predicted gene, 33433 Neighboring gene glutathione reductase Neighboring gene predicted gene, 24727

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
UBX domain-containing protein 8
Names
UBX domain containing 6
UBX domain-containing protein 6
protein Rep-8
reproduction 8 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178648.2NP_848763.2  UBX domain-containing protein 8

    See identical proteins and their annotated locations for NP_848763.2

    Status: VALIDATED

    Source sequence(s)
    AK132565, AK161397, BY613198
    Consensus CDS
    CCDS22234.1
    UniProtKB/Swiss-Prot
    Q9QZ49
    UniProtKB/TrEMBL
    Q3TTF2
    Related
    ENSMUSP00000092992.5, ENSMUST00000095349.6
    Conserved Domains (1) summary
    cl00155
    Location:192271
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    34109614..34135515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508980.5XP_006509043.1  UBX domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ49
    Conserved Domains (2) summary
    cd01774
    Location:150225
    UBX_UBXN8; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 8 (UBXN8) and similar proteins
    pfam09751
    Location:67171
    Es2; Nuclear protein Es2