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Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) [ Mus musculus (house mouse) ]

Gene ID: 108155, updated on 18-Apr-2024

Summary

Official Symbol
Ogtprovided by MGI
Official Full Name
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)provided by MGI
Primary source
MGI:MGI:1339639
See related
Ensembl:ENSMUSG00000034160 AllianceGenome:MGI:1339639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ogtl; 1110038P24Rik; 4831420N21Rik
Summary
Enables protein O-GlcNAc transferase activity. Involved in several processes, including circadian regulation of gene expression; positive regulation of cold-induced thermogenesis; and regulation of gluconeogenesis. Acts upstream of or within protein O-linked glycosylation. Predicted to be located in several cellular components, including euchromatin; neuronal cell body; and zymogen granule. Predicted to be part of histone acetyltransferase complex and protein N-acetylglucosaminyltransferase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 101.0), CNS E18 (RPKM 90.5) and 25 other tissues See more
Orthologs
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Genomic context

Location:
X D; X 44.45 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100683617..100727957)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101640011..101684351)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2537 Neighboring gene ring finger protein 26 pseudogene Neighboring gene TATA-box binding protein associated factor 1 Neighboring gene STARR-seq mESC enhancer starr_47657 Neighboring gene STARR-seq mESC enhancer starr_47659 Neighboring gene RNA binding protein pseudogene Neighboring gene predicted gene, 52429

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Gene trapped (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
enables catalytic activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables protein N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein O-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein O-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein O-acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein O-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucosamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular distribution of mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in mitophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within protein O-linked glycosylation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse assembly IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of NSL complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cerebellar granule cell to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of protein N-acetylglucosaminyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IEP
Inferred from Expression Pattern
more info
PubMed 
located_in zymogen granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Names
O-GlcNAc transferase subunit p110
O-linked N-acetylglucosamine transferase 110 kDa subunit
NP_001277464.1
NP_631883.2
XP_006527799.1
XP_011245805.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290535.1NP_001277464.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2

    See identical proteins and their annotated locations for NP_001277464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK045910, BC057319, CB520299, CD544482
    Consensus CDS
    CCDS72415.1
    UniProtKB/Swiss-Prot
    Q8CGY8
    Conserved Domains (3) summary
    TIGR02917
    Location:23455
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:317345
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:5461014
    Glyco_transf_41; Glycosyl transferase family 41
  2. NM_139144.4NP_631883.2  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1

    See identical proteins and their annotated locations for NP_631883.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK045910, BC057319, BY196484, CF166269
    Consensus CDS
    CCDS30318.1
    UniProtKB/Swiss-Prot
    A2ALY1, Q6PG10, Q8BXH6, Q8CGY8, Q91Y38
    Related
    ENSMUSP00000045409.5, ENSMUST00000044475.5
    Conserved Domains (3) summary
    TIGR02917
    Location:22465
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:327355
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:5561024
    Glyco_transf_41; Glycosyl transferase family 41

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    100683617..100727957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527736.4XP_006527799.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1

    See identical proteins and their annotated locations for XP_006527799.1

    UniProtKB/Swiss-Prot
    A2ALY1, Q6PG10, Q8BXH6, Q8CGY8, Q91Y38
    Conserved Domains (3) summary
    TIGR02917
    Location:22465
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:327355
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:5561024
    Glyco_transf_41; Glycosyl transferase family 41
  2. XM_011247503.2XP_011245805.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X2

    See identical proteins and their annotated locations for XP_011245805.1

    UniProtKB/Swiss-Prot
    Q8CGY8
    Related
    ENSMUSP00000113454.2, ENSMUST00000119299.8
    Conserved Domains (3) summary
    TIGR02917
    Location:23455
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:317345
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:5461014
    Glyco_transf_41; Glycosyl transferase family 41