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CPLX1 complexin 1 [ Homo sapiens (human) ]

Gene ID: 10815, updated on 25-Nov-2021

Summary

Official Symbol
CPLX1provided by HGNC
Official Full Name
complexin 1provided by HGNC
Primary source
HGNC:HGNC:2309
See related
Ensembl:ENSG00000168993 MIM:605032
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPX1; CPX-I; DEE63; EIEE63
Summary
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 19.8), fat (RPKM 3.8) and 5 other tissues See more
Orthologs
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Genomic context

See CPLX1 in Genome Data Viewer
Location:
4p16.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (784957..826129, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (778745..819917, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene polycomb group ring finger 3 Neighboring gene uncharacterized LOC107986246 Neighboring gene uncharacterized LOC100129917 Neighboring gene uncharacterized LOC105374339 Neighboring gene uncharacterized LOC105374340 Neighboring gene uncharacterized LOC105374341 Neighboring gene cyclin G associated kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neurotransmitter transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in calyx of Held IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
part_of synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex TAS
Traceable Author Statement
more info
PubMed 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
complexin-1
Names
CPX I
complexin I
synaphin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006651.4NP_006642.1  complexin-1

    See identical proteins and their annotated locations for NP_006642.1

    Status: REVIEWED

    Source sequence(s)
    AC139887
    Consensus CDS
    CCDS46995.1
    UniProtKB/Swiss-Prot
    O14810
    Related
    ENSP00000305613.6, ENST00000304062.11
    Conserved Domains (1) summary
    pfam05835
    Location:1133
    Synaphin; Synaphin protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    784957..826129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513391.1XP_011511693.1  complexin-1 isoform X1

    Related
    ENSP00000421947.1, ENST00000504062.1
    Conserved Domains (1) summary
    pfam05835
    Location:1118
    Synaphin; Synaphin protein
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