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Fermt3 fermitin family member 3 [ Mus musculus (house mouse) ]

Gene ID: 108101, updated on 15-Apr-2019

Summary

Official Symbol
Fermt3provided by MGI
Official Full Name
fermitin family member 3provided by MGI
Primary source
MGI:MGI:2147790
See related
Ensembl:ENSMUSG00000024965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C79673; Kindlin3
Expression
Biased expression in thymus adult (RPKM 110.9), spleen adult (RPKM 102.1) and 13 other tissues See more
Orthologs

Genomic context

See Fermt3 in Genome Data Viewer
Location:
19; 19 A
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (6998958..7019469, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (7073448..7093959, complement)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene predicted gene, 35838 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 22 Neighboring gene tRNA phosphotransferase 1 Neighboring gene stress-induced phosphoprotein 1 Neighboring gene MACRO domain containing 1 Neighboring gene RIKEN cDNA 5730409K12 gene Neighboring gene fibronectin leucine rich transmembrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC36836, MGC38286

Gene Ontology Provided by MGI

Function Evidence Code Pubs
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
integrin activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin activation ISO
Inferred from Sequence Orthology
more info
 
integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of cell-cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
podosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fermitin family homolog 3
Names
unc-112-related protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362399.1NP_001349328.1  fermitin family homolog 3

    Status: VALIDATED

    Source sequence(s)
    AC120557, AC163098
    Conserved Domains (4) summary
    smart00295
    Location:221301
    B41; Band 4.1 homologues
    cd01237
    Location:350474
    PH_fermitin; Fermitin family pleckstrin homology (PH) domain
    cd13205
    Location:550641
    FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
    pfam00373
    Location:490555
    FERM_M; FERM central domain
  2. NM_153795.2NP_722490.1  fermitin family homolog 3

    See identical proteins and their annotated locations for NP_722490.1

    Status: VALIDATED

    Source sequence(s)
    AC163098, AK142912
    Consensus CDS
    CCDS29518.1
    UniProtKB/Swiss-Prot
    Q8K1B8
    UniProtKB/TrEMBL
    Q3TEE6
    Related
    ENSMUSP00000037858.8, ENSMUST00000040772.8
    Conserved Domains (4) summary
    smart00295
    Location:221301
    B41; Band 4.1 homologues
    cd01237
    Location:350474
    PH_fermitin; Fermitin family pleckstrin homology (PH) domain
    cd13205
    Location:550641
    FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
    pfam00373
    Location:490555
    FERM_M; FERM central domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

    Range
    6998958..7019469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526593.3XP_006526656.1  fermitin family homolog 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8K1B8
    UniProtKB/TrEMBL
    Q3TEE6
    Conserved Domains (4) summary
    smart00295
    Location:221301
    B41; Band 4.1 homologues
    cd01237
    Location:350474
    PH_fermitin; Fermitin family pleckstrin homology (PH) domain
    cd13205
    Location:550641
    FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
    pfam00373
    Location:490555
    FERM_M; FERM central domain
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