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CGA glycoprotein hormones, alpha polypeptide [ Homo sapiens (human) ]

Gene ID: 1081, updated on 8-Jul-2021

Summary

Official Symbol
CGAprovided by HGNC
Official Full Name
glycoprotein hormones, alpha polypeptideprovided by HGNC
Primary source
HGNC:HGNC:1885
See related
Ensembl:ENSG00000135346 MIM:118850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCG; LHA; FSHA; GPA1; GPHa; TSHA; GPHA1; CG-ALPHA
Summary
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Restricted expression toward placenta (RPKM 388.3) See more
Orthologs
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Genomic context

See CGA in Genome Data Viewer
Location:
6q14.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (87085498..87095106, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (87795216..87804824, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 1E Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 2 Neighboring gene RN7SK pseudogene 209 Neighboring gene reticulocalbin 1 pseudogene 1 Neighboring gene RNA polymerase I subunit F pseudogene Neighboring gene zinc finger protein 292

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables follicle-stimulating hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables follicle-stimulating hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hormone activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in developmental growth IEA
Inferred from Electronic Annotation
more info
 
involved_in follicle-stimulating hormone secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in gonad development IEA
Inferred from Electronic Annotation
more info
 
involved_in luteinizing hormone secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of steroid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
involved_in thyroid hormone generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
part_of follicle-stimulating hormone complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of follicle-stimulating hormone complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glycoprotein hormones alpha chain
Names
FSH-alpha
LSH-alpha
TSH-alpha
anterior pituitary glycoprotein hormones common subunit alpha
choriogonadotropin alpha chain
chorionic gonadotrophin subunit alpha
chorionic gonadotropin, alpha polypeptide
follicle-stimulating hormone alpha chain
follicle-stimulating hormone alpha subunit
follitropin alpha chain
luteinizing hormone alpha chain
lutropin alpha chain
thyroid-stimulating hormone alpha chain
thyrotropin alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000735.4NP_000726.1  glycoprotein hormones alpha chain isoform 2 precursor

    See identical proteins and their annotated locations for NP_000726.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI200485, BC055080, BG619154
    Consensus CDS
    CCDS5007.1
    UniProtKB/Swiss-Prot
    P01215
    UniProtKB/TrEMBL
    Q6I9S8
    Related
    ENSP00000486024.1, ENST00000627148.3
    Conserved Domains (1) summary
    pfam00236
    Location:28109
    Hormone_6; Glycoprotein hormone
  2. NM_001252383.2NP_001239312.1  glycoprotein hormones alpha chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_001239312.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI200485, BC055080, BG571584, BG619154
    Consensus CDS
    CCDS75492.1
    UniProtKB/Swiss-Prot
    P01215
    UniProtKB/TrEMBL
    A0A087WYZ4
    Related
    ENSP00000482232.1, ENST00000610310.3
    Conserved Domains (1) summary
    pfam00236
    Location:60140
    Hormone_6; Glycoprotein hormone

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    87085498..87095106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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