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Prkab2 protein kinase, AMP-activated, beta 2 non-catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 108097, updated on 27-Nov-2024

Summary

Official Symbol
Prkab2provided by MGI
Official Full Name
protein kinase, AMP-activated, beta 2 non-catalytic subunitprovided by MGI
Primary source
MGI:MGI:1336185
See related
Ensembl:ENSMUSG00000038205 AllianceGenome:MGI:1336185
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730553K21Rik
Summary
Predicted to enable protein kinase binding activity. Predicted to contribute to AMP-activated protein kinase activity. Involved in positive regulation of cold-induced thermogenesis. Predicted to be located in apical plasma membrane. Predicted to be part of cAMP-dependent protein kinase complex and nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; gallbladder; genitourinary system; and nervous system. Orthologous to human PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 27.2), heart adult (RPKM 10.1) and 23 other tissues See more
Orthologs
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Genomic context

See Prkab2 in Genome Data Viewer
Location:
3 F2.2; 3 42.25 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (97565527..97581128)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (97658211..97673812)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08468 Neighboring gene predicted gene, 40102 Neighboring gene chromodomain helicase DNA binding protein 1-like Neighboring gene flavin containing monooxygenase 5 Neighboring gene STARR-positive B cell enhancer ABC_E9010 Neighboring gene STARR-positive B cell enhancer ABC_E6086 Neighboring gene nuclear encoded tRNA glutamine 2 (anticodon CTG) Neighboring gene predicted gene, 31242 Neighboring gene phosphodiesterase 4D interacting protein (myomegalin) Neighboring gene microRNA 7225

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to AMP-activated protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables AMP-activated protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nutrient levels NAS
Non-traceable Author Statement
more info
PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cold-induced thermogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of cAMP-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nucleotide-activated protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
part_of nucleotide-activated protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
5'-AMP-activated protein kinase subunit beta-2
Names
AMPK subunit beta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182997.2NP_892042.2  5'-AMP-activated protein kinase subunit beta-2

    See identical proteins and their annotated locations for NP_892042.2

    Status: PROVISIONAL

    Source sequence(s)
    BC060228
    Consensus CDS
    CCDS17657.1
    UniProtKB/Swiss-Prot
    Q6PAM0
    Related
    ENSMUSP00000036410.7, ENSMUST00000045743.13
    Conserved Domains (2) summary
    smart01010
    Location:182271
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:76158
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    97565527..97581128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252348.1XP_030108208.1  5'-AMP-activated protein kinase subunit beta-2 isoform X2

    Conserved Domains (2) summary
    smart01010
    Location:138227
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:32114
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
  2. XM_011239982.4XP_011238284.1  5'-AMP-activated protein kinase subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_011238284.1

    UniProtKB/Swiss-Prot
    Q6PAM0
    Conserved Domains (2) summary
    smart01010
    Location:182271
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:76158
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
  3. XM_006500840.3XP_006500903.1  5'-AMP-activated protein kinase subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006500903.1

    UniProtKB/Swiss-Prot
    Q6PAM0
    Conserved Domains (2) summary
    smart01010
    Location:182271
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:76158
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
  4. XM_006500841.3XP_006500904.1  5'-AMP-activated protein kinase subunit beta-2 isoform X2

    Conserved Domains (2) summary
    smart01010
    Location:138227
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:32114
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase