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STARD10 StAR related lipid transfer domain containing 10 [ Homo sapiens (human) ]

Gene ID: 10809, updated on 5-Mar-2024

Summary

Official Symbol
STARD10provided by HGNC
Official Full Name
StAR related lipid transfer domain containing 10provided by HGNC
Primary source
HGNC:HGNC:10666
See related
Ensembl:ENSG00000214530 MIM:617382; AllianceGenome:HGNC:10666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCTP2; CGI-52; NY-CO-28; SDCCAG28
Summary
Predicted to enable lipid binding activity. Predicted to be involved in lipid transport. Predicted to act upstream of or within bile acid secretion and positive regulation of peroxisome proliferator activated receptor signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver (RPKM 47.9), stomach (RPKM 44.9) and 23 other tissues See more
Orthologs
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Genomic context

See STARD10 in Genome Data Viewer
Location:
11q13.4
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (72754729..72794047, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (72682966..72722274, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (72465774..72505092, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72415096-72415932 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72417010-72417596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72420686-72421388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72423687-72424267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72424849-72425428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72428169-72428669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72428974-72429474 Neighboring gene ARAP1 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5196 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Neighboring gene ribosomal protein S12 pseudogene 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72452199-72452976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72453754-72454530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72485809-72486308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72493384-72494086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72497138-72498136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72498137-72499133 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72503217-72503716 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5206 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:72509227-72509964 Neighboring gene uncharacterized LOC107984421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3731 Neighboring gene microRNA 4692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72537383-72537883 Neighboring gene autophagy related 16 like 2 Neighboring gene FCH and double SH3 domains 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ARAP1

Clone Names

  • MGC14401

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in intercellular canaliculus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
START domain-containing protein 10
Names
PCTP-L
PCTP-like protein
START domain containing 10
StAR-related lipid transfer (START) domain containing 10
antigen NY-CO-28
serologically defined colon cancer antigen 28
stAR-related lipid transfer protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006645.3NP_006636.2  START domain-containing protein 10

    See identical proteins and their annotated locations for NP_006636.2

    Status: VALIDATED

    Source sequence(s)
    AP002381, AP003065
    Consensus CDS
    CCDS41688.1
    UniProtKB/Swiss-Prot
    O60532, Q9Y365
    UniProtKB/TrEMBL
    B3KTJ1
    Related
    ENSP00000335247.6, ENST00000334805.11
    Conserved Domains (1) summary
    cd08871
    Location:19241
    START_STARD10-like; Lipid-binding START domain of mammalian STARD10 and related proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    72754729..72794047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    72682966..72722274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)