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Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 108078, updated on 11-Apr-2024

Summary

Official Symbol
Olr1provided by MGI
Official Full Name
oxidized low density lipoprotein (lectin-like) receptor 1provided by MGI
Primary source
MGI:MGI:1261434
See related
Ensembl:ENSMUSG00000030162 AllianceGenome:MGI:1261434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LOX-1; SR-EI; Scare1
Summary
Enables low-density lipoprotein particle receptor activity. Predicted to be involved in several processes, including inflammatory response; leukocyte cell-cell adhesion; and lipoprotein metabolic process. Predicted to act upstream of or within cell adhesion and immune system process. Predicted to be located in nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in blood vessel; embryo; heart; and primitive ventricle. Human ortholog(s) of this gene implicated in cerebral amyloid angiopathy; coronary artery disease; and myocardial infarction. Orthologous to human OLR1 (oxidized low density lipoprotein receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 10.0), lung adult (RPKM 1.0) and 2 other tissues See more
Orthologs
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Genomic context

See Olr1 in Genome Data Viewer
Location:
6 F3; 6 63.35 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129456113..129484312, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129479150..129507350, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 12, member B Neighboring gene STARR-positive B cell enhancer mm9_chr6:129384284-129384585 Neighboring gene C-type lectin domain family 1, member a Neighboring gene STARR-seq mESC enhancer starr_17480 Neighboring gene predicted gene, 45969 Neighboring gene C-type lectin domain family 7, member a Neighboring gene transmembrane protein 52B Neighboring gene RIKEN cDNA 1700101I11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:129481855-129482155 Neighboring gene GABA type A receptor associated protein like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables low-density lipoprotein particle receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables low-density lipoprotein particle receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in lipoprotein metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vesicle-mediated transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extrinsic component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
oxidized low-density lipoprotein receptor 1
Names
lectin-like oxLDL receptor 1
lectin-like oxidized LDL receptor 1
lectin-type oxidized LDL receptor 1
ox-LDL receptor 1
oxidised low density lipoprotein (lectin-like) receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301094.1NP_001288023.1  oxidized low-density lipoprotein receptor 1 isoform 3

    See identical proteins and their annotated locations for NP_001288023.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC161602, BX513847
    Consensus CDS
    CCDS80620.1
    UniProtKB/TrEMBL
    G4WK10
    Related
    ENSMUSP00000138588.2, ENSMUST00000182784.4
    Conserved Domains (1) summary
    cd03593
    Location:61182
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  2. NM_001301096.1NP_001288025.1  oxidized low-density lipoprotein receptor 1 isoform 2

    See identical proteins and their annotated locations for NP_001288025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC161602, BX513847
    Consensus CDS
    CCDS80619.1
    UniProtKB/TrEMBL
    G4WK09
    Related
    ENSMUSP00000138228.2, ENSMUST00000183258.8
    Conserved Domains (1) summary
    cd03593
    Location:27148
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  3. NM_138648.2NP_619589.2  oxidized low-density lipoprotein receptor 1 isoform 1

    See identical proteins and their annotated locations for NP_619589.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK160919, BX513847
    Consensus CDS
    CCDS20588.1
    UniProtKB/Swiss-Prot
    Q3U3M1, Q9EQ09
    Related
    ENSMUSP00000032265.7, ENSMUST00000032265.13
    Conserved Domains (4) summary
    cd03593
    Location:235356
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam01442
    Location:71229
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam06273
    Location:156214
    eIF-4B; Plant specific eukaryotic initiation factor 4B
    cl12057
    Location:96175
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    129456113..129484312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321299.3XP_017176788.1  oxidized low-density lipoprotein receptor 1 isoform X1

    Conserved Domains (2) summary
    cd03593
    Location:189310
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    TIGR02168
    Location:58184
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  2. XM_017321300.1XP_017176789.1  oxidized low-density lipoprotein receptor 1 isoform X2

    Conserved Domains (2) summary
    cd03593
    Location:152273
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    TIGR02168
    Location:3147
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_001785081.3 RNA Sequence