U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eif2b3 eukaryotic translation initiation factor 2B, subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 108067, updated on 26-Sep-2022

Summary

Official Symbol
Eif2b3provided by MGI
Official Full Name
eukaryotic translation initiation factor 2B, subunit 3provided by MGI
Primary source
MGI:MGI:1313286
See related
Ensembl:ENSMUSG00000028683 AllianceGenome:MGI:1313286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1190002P15Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to contribute to translation factor activity, RNA binding. Predicted to be involved in several processes, including T cell receptor signaling pathway; cytoplasmic translational initiation; and oligodendrocyte development. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Is expressed in central nervous system; gonad; retina; and thyroid gland. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 4.2), CNS E11.5 (RPKM 4.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Eif2b3 in Genome Data Viewer
Location:
4; 4 D1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116876559..116944049)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117019399..117086852)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 3 Neighboring gene tetraspanin 17 pseudogene Neighboring gene predicted gene, 22335 Neighboring gene Ptch2 Hedgehog-responsive enhancers Neighboring gene patched 2 Neighboring gene BTB (POZ) domain containing 19 Neighboring gene dynein light chain Tctex-type 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to translation factor activity, RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oligodendrocyte development ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of eukaryotic translation initiation factor 2B complex ISO
Inferred from Sequence Orthology
more info
 
part_of guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
translation initiation factor eIF-2B subunit gamma

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111277.2NP_001104747.1  translation initiation factor eIF-2B subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_001104747.1

    Status: VALIDATED

    Source sequence(s)
    AK145856, BC115657, BE952243, BQ828648, BY277686
    Consensus CDS
    CCDS51279.1
    UniProtKB/TrEMBL
    B1AUN2
    Related
    ENSMUSP00000102056.3, ENSMUST00000106448.9
    Conserved Domains (3) summary
    cd04652
    Location:357437
    LbH_eIF2B_gamma_C; eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...
    cd04198
    Location:3212
    eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
    COG1208
    Location:4447
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
  2. NM_001355225.1NP_001342154.1  translation initiation factor eIF-2B subunit gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK145856, BE952243, BM945817, BQ176818, BQ828648, BY277686, DV041891
    Conserved Domains (1) summary
    cd04652
    Location:142222
    LbH_eIF2B_gamma_C; eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...
  3. NM_175135.5NP_780344.2  translation initiation factor eIF-2B subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_780344.2

    Status: VALIDATED

    Source sequence(s)
    AK145856, AK165157, BQ828648, BY277686
    Consensus CDS
    CCDS18524.1
    UniProtKB/TrEMBL
    Q3UKV0
    Related
    ENSMUSP00000102055.3, ENSMUST00000106447.9
    Conserved Domains (3) summary
    cd04198
    Location:3212
    eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
    COG1208
    Location:4399
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
    cl00160
    Location:357401
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    116876559..116944049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502649.3XP_006502712.1  translation initiation factor eIF-2B subunit gamma isoform X1

    Conserved Domains (2) summary
    cd04198
    Location:3212
    eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
    cl00160
    Location:357401
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...