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SEC24A SEC24 homolog A, COPII coat complex component [ Homo sapiens (human) ]

Gene ID: 10802, updated on 8-Aug-2021

Summary

Official Symbol
SEC24Aprovided by HGNC
Official Full Name
SEC24 homolog A, COPII coat complex componentprovided by HGNC
Primary source
HGNC:HGNC:10703
See related
Ensembl:ENSG00000113615 MIM:607183
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in small intestine (RPKM 10.1), duodenum (RPKM 10.0) and 25 other tissues See more
Orthologs
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Genomic context

See SEC24A in Genome Data Viewer
Location:
5q31.1
Exon count:
26
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (134647757..134727909)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133984475..134063599)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene secretion associated Ras related GTPase 1B Neighboring gene HNF4 motif-containing MPRA enhancer 267 Neighboring gene RNA, U6 small nuclear 1311, pseudogene Neighboring gene RNA, U6 small nuclear 1164, pseudogene Neighboring gene RNA, U6 small nuclear 757, pseudogene Neighboring gene calcium modulating ligand Neighboring gene DEAD-box helicase 46 Neighboring gene ribosomal protein L34 pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of COPII vesicle coat IDA
Inferred from Direct Assay
more info
PubMed 
located_in ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein transport protein Sec24A
Names
SEC24 family, member A
SEC24 related gene family, member A
SEC24-related protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252231.2NP_001239160.1  protein transport protein Sec24A isoform 2

    See identical proteins and their annotated locations for NP_001239160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several exons from the 3' end, and contains an alternate 3' terminal exon compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK304060, BC019341
    Consensus CDS
    CCDS58967.1
    UniProtKB/Swiss-Prot
    O95486
    UniProtKB/TrEMBL
    B4E205
    Related
    ENSP00000321749.4, ENST00000322887.8
    Conserved Domains (3) summary
    pfam04810
    Location:428464
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam15834
    Location:92143
    THEG4; Testis highly expressed protein 4
    cl00057
    Location:501595
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  2. NM_021982.3NP_068817.1  protein transport protein Sec24A isoform 1

    See identical proteins and their annotated locations for NP_068817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AJ131244, AK304060, BC019341, BM127845, CD677660
    Consensus CDS
    CCDS43363.1
    UniProtKB/Swiss-Prot
    O95486
    UniProtKB/TrEMBL
    B4E205
    Related
    ENSP00000381823.2, ENST00000398844.7
    Conserved Domains (7) summary
    COG5028
    Location:2371093
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:501743
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:9641039
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:428464
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:843938
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:744828
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
    pfam15834
    Location:92158
    THEG4; Testis highly expressed protein 4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    134647757..134727909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008961.2XP_016864450.1  protein transport protein Sec24A isoform X1

  2. XM_006714523.3XP_006714586.1  protein transport protein Sec24A isoform X2

    Conserved Domains (7) summary
    COG5028
    Location:1721035
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:443685
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:906981
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:370406
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:785880
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:686770
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
    pfam15834
    Location:92158
    THEG4; Testis highly expressed protein 4
  3. XM_017008963.2XP_016864452.1  protein transport protein Sec24A isoform X4

  4. XM_017008962.1XP_016864451.1  protein transport protein Sec24A isoform X3

RNA

  1. XR_948228.3 RNA Sequence

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