U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cenpf centromere protein F [ Mus musculus (house mouse) ]

Gene ID: 108000, updated on 5-Jan-2023

Summary

Official Symbol
Cenpfprovided by MGI
Official Full Name
centromere protein Fprovided by MGI
Primary source
MGI:MGI:1313302
See related
Ensembl:ENSMUSG00000026605 AllianceGenome:MGI:1313302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CENF; Lek1; PRO1779; mitosin; 6530404A22Rik
Summary
Predicted to enable several functions, including dynein complex binding activity; protein C-terminus binding activity; and protein homodimerization activity. Acts upstream of or within regulation of striated muscle tissue development. Located in cytoskeleton and pronucleus. Part of ciliary transition fiber. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and limb. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Stromme syndrome. Orthologous to human CENPF (centromere protein F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 9.3), liver E14 (RPKM 4.4) and 10 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cenpf in Genome Data Viewer
Location:
1 H6; 1 95.03 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (189372803..189420302, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (189640606..189688107, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46177 Neighboring gene predicted gene, 30088 Neighboring gene protein tyrosine phosphatase, non-receptor type 14 Neighboring gene predicted gene, 51739 Neighboring gene predicted gene, 30280

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in metaphase plate congression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of striated muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ventricular system development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
part_of ciliary transition fiber IDA
Inferred from Direct Assay
more info
PubMed 
part_of ciliary transition fiber ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
NOT located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of outer kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
centromere protein F
Names
centromere autoantigen F
leucine, glutamic acid, lysine family 1 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081363.2NP_001074832.2  centromere protein F

    Status: VALIDATED

    Source sequence(s)
    AC140679
    Consensus CDS
    CCDS35820.2
    UniProtKB/TrEMBL
    E9Q3P4
    Related
    ENSMUSP00000129738.2, ENSMUST00000171929.8
    Conserved Domains (5) summary
    COG0419
    Location:9151363
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02168
    Location:2901122
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10473
    Location:23132449
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam10481
    Location:1300
    CENP-F_N; Cenp-F N-terminal domain
    pfam10490
    Location:28502896
    CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    189372803..189420302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497119.4XP_006497182.1  centromere protein F isoform X1

    Conserved Domains (6) summary
    COG0419
    Location:8431291
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:18652702
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:2181050
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10473
    Location:22412377
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam10481
    Location:1228
    CENP-F_N; Cenp-F N-terminal domain
    pfam10490
    Location:27782824
    CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1