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CYSLTR1 cysteinyl leukotriene receptor 1 [ Homo sapiens (human) ]

Gene ID: 10800, updated on 9-Dec-2024

Summary

Official Symbol
CYSLTR1provided by HGNC
Official Full Name
cysteinyl leukotriene receptor 1provided by HGNC
Primary source
HGNC:HGNC:17451
See related
Ensembl:ENSG00000173198 MIM:300201; AllianceGenome:HGNC:17451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYSLT1; CYSLTR; CYSLT1R; HMTMF81
Summary
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Broad expression in urinary bladder (RPKM 6.1), spleen (RPKM 5.2) and 20 other tissues See more
Orthologs
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Genomic context

See CYSLTR1 in Genome Data Viewer
Location:
Xq21.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (78271468..78327611, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (76708793..76764940, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (77526965..77583108, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 3C, pseudogene Neighboring gene uncharacterized LOC107985669 Neighboring gene MPRA-validated peak7397 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29787 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:77769873-77770852 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 34 Neighboring gene UBE2V1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of cysteinyl leukotriene receptor 1 (CYSLTR1) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC46139

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteinyl leukotriene receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables leukotriene receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response TAS
Traceable Author Statement
more info
PubMed 
involved_in establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in leukotriene signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytosolic calcium ion concentration TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
involved_in respiratory gaseous exchange by respiratory system TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cysteinyl leukotriene receptor 1
Names
G-protein coupled receptor HG55
LTD4 receptor
cysteinyl leukotriene D4 receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012809.1 RefSeqGene

    Range
    4980..61123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282186.2NP_001269115.1  cysteinyl leukotriene receptor 1

    See identical proteins and their annotated locations for NP_001269115.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AF133266, DQ131799, DQ131800, DQ131803
    Consensus CDS
    CCDS14439.1
    UniProtKB/Swiss-Prot
    B2R954, D3DTE4, Q5JS94, Q8IV19, Q9Y271
    Related
    ENSP00000478492.1, ENST00000614798.1
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32163
    7tm_4; Olfactory receptor
  2. NM_001282187.2NP_001269116.1  cysteinyl leukotriene receptor 1

    See identical proteins and their annotated locations for NP_001269116.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AF133266, DQ131799, DQ131801, DQ131803
    Consensus CDS
    CCDS14439.1
    UniProtKB/Swiss-Prot
    B2R954, D3DTE4, Q5JS94, Q8IV19, Q9Y271
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32163
    7tm_4; Olfactory receptor
  3. NM_001282188.2NP_001269117.1  cysteinyl leukotriene receptor 1

    See identical proteins and their annotated locations for NP_001269117.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AF133266, DQ131799, DQ131802, DQ131803
    Consensus CDS
    CCDS14439.1
    UniProtKB/Swiss-Prot
    B2R954, D3DTE4, Q5JS94, Q8IV19, Q9Y271
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32163
    7tm_4; Olfactory receptor
  4. NM_006639.4NP_006630.1  cysteinyl leukotriene receptor 1

    See identical proteins and their annotated locations for NP_006630.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AF133266, DQ131799, DQ131803
    Consensus CDS
    CCDS14439.1
    UniProtKB/Swiss-Prot
    B2R954, D3DTE4, Q5JS94, Q8IV19, Q9Y271
    Related
    ENSP00000362401.3, ENST00000373304.4
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32163
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    78271468..78327611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    76708793..76764940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)