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CYSLTR1 cysteinyl leukotriene receptor 1 [ Homo sapiens (human) ]

Gene ID: 10800, updated on 21-Dec-2019

Summary

Official Symbol
CYSLTR1provided by HGNC
Official Full Name
cysteinyl leukotriene receptor 1provided by HGNC
Primary source
HGNC:HGNC:17451
See related
Ensembl:ENSG00000173198 MIM:300201
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYSLT1; CYSLTR; CYSLT1R; HMTMF81
Summary
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Broad expression in urinary bladder (RPKM 6.1), spleen (RPKM 5.2) and 20 other tissues See more
Orthologs

Genomic context

See CYSLTR1 in Genome Data Viewer
Location:
Xq21.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (78271468..78327691, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (77526965..77583193, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 3C, pseudogene Neighboring gene uncharacterized LOC107985669 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 34 Neighboring gene ubiquitin conjugating enzyme E2 V1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of cysteinyl leukotriene receptor 1 (CYSLTR1) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC46139

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
galanin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukotriene receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
leukotriene signaling pathway IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration TAS
Traceable Author Statement
more info
PubMed 
respiratory gaseous exchange TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cysteinyl leukotriene receptor 1
Names
G-protein coupled receptor HG55
LTD4 receptor
cysteinyl leukotriene D4 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012809.1 RefSeqGene

    Range
    4980..61123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282186.1NP_001269115.1  cysteinyl leukotriene receptor 1

    See identical proteins and their annotated locations for NP_001269115.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AF133266, DQ131799, DQ131800, DQ131803
    Consensus CDS
    CCDS14439.1
    UniProtKB/Swiss-Prot
    Q9Y271
    UniProtKB/TrEMBL
    Q38Q88, Q38Q91
    Related
    ENSP00000478492.1, ENST00000614798.1
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32163
    7tm_4; Olfactory receptor
  2. NM_001282187.2NP_001269116.1  cysteinyl leukotriene receptor 1

    See identical proteins and their annotated locations for NP_001269116.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AF133266, DQ131799, DQ131801, DQ131803
    Consensus CDS
    CCDS14439.1
    UniProtKB/Swiss-Prot
    Q9Y271
    UniProtKB/TrEMBL
    Q38Q88, Q38Q91
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32163
    7tm_4; Olfactory receptor
  3. NM_001282188.2NP_001269117.1  cysteinyl leukotriene receptor 1

    See identical proteins and their annotated locations for NP_001269117.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AF133266, DQ131799, DQ131802, DQ131803
    Consensus CDS
    CCDS14439.1
    UniProtKB/Swiss-Prot
    Q9Y271
    UniProtKB/TrEMBL
    Q38Q88, Q38Q91
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32163
    7tm_4; Olfactory receptor
  4. NM_006639.4NP_006630.1  cysteinyl leukotriene receptor 1

    See identical proteins and their annotated locations for NP_006630.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AF133266, DQ131799, DQ131803
    Consensus CDS
    CCDS14439.1
    UniProtKB/Swiss-Prot
    Q9Y271
    UniProtKB/TrEMBL
    Q38Q88, Q38Q91
    Related
    ENSP00000362401.3, ENST00000373304.4
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32163
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    78271468..78327691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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