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RPP40 ribonuclease P/MRP subunit p40 [ Homo sapiens (human) ]

Gene ID: 10799, updated on 7-Jun-2020

Summary

Official Symbol
RPP40provided by HGNC
Official Full Name
ribonuclease P/MRP subunit p40provided by HGNC
Primary source
HGNC:HGNC:20992
See related
Ensembl:ENSG00000124787 MIM:606117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNASEP1; bA428J1.3
Expression
Ubiquitous expression in adrenal (RPKM 3.2), testis (RPKM 2.4) and 25 other tissues See more
Orthologs

Genomic context

See RPP40 in Genome Data Viewer
Location:
6p25.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (4992405..5004063, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (4995280..5004292, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene chromodomain Y like Neighboring gene uncharacterized LOC105374897 Neighboring gene ribosomal protein S18 pseudogene 8 Neighboring gene LYRM4 antisense RNA 1 Neighboring gene LYR motif containing 4 Neighboring gene transcription factor B2, mitochondrial pseudogene Neighboring gene protein phosphatase 1 regulatory subunit 3G

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ribonuclease P/MRP 40kDa subunit (RPP40) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ribonuclease MRP activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease P RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ribonuclease P activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
multimeric ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multimeric ribonuclease P complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolar ribonuclease P complex TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ribonuclease P protein subunit p40
Names
RNase P subunit 1
RNaseP protein p40
ribonuclease P (40 kD)
ribonuclease P, 40kD subunit
ribonuclease P/MRP 40kDa subunit
ribonuclease P1
NP_001273061.1
NP_001273062.1
NP_006629.2
XP_011512555.1
XP_024302077.1
XP_024302078.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286132.2NP_001273061.1  ribonuclease P protein subunit p40 isoform b

    See identical proteins and their annotated locations for NP_001273061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AL359643, BC017871, BM015573, BU607286, BX951376
    Consensus CDS
    CCDS69040.1
    UniProtKB/Swiss-Prot
    O75818
    Related
    ENSP00000317998.5, ENST00000319533.9
    Conserved Domains (1) summary
    pfam08584
    Location:75320
    Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit
  2. NM_001286133.1NP_001273062.1  ribonuclease P protein subunit p40 isoform c

    See identical proteins and their annotated locations for NP_001273062.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    BC017871, BM827175, BU607286, BX951376
    Consensus CDS
    CCDS75391.1
    UniProtKB/Swiss-Prot
    O75818
    UniProtKB/TrEMBL
    A0A087X1N3
    Related
    ENSP00000484334.1, ENST00000618533.4
    Conserved Domains (1) summary
    pfam08584
    Location:75301
    Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit
  3. NM_006638.4NP_006629.2  ribonuclease P protein subunit p40 isoform a

    See identical proteins and their annotated locations for NP_006629.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL359643, BC017871, BQ220155, BU607286, BX951376
    Consensus CDS
    CCDS34333.1
    UniProtKB/Swiss-Prot
    O75818
    Related
    ENSP00000369391.2, ENST00000380051.7
    Conserved Domains (1) summary
    pfam08584
    Location:75343
    Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    4992405..5004063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446309.1XP_024302077.1  ribonuclease P protein subunit p40 isoform X2

    Conserved Domains (1) summary
    pfam08584
    Location:75255
    Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit
  2. XM_011514253.2XP_011512555.1  ribonuclease P protein subunit p40 isoform X1

    Conserved Domains (1) summary
    pfam08584
    Location:75297
    Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit
  3. XM_024446310.1XP_024302078.1  ribonuclease P protein subunit p40 isoform X3

    Conserved Domains (1) summary
    pfam08584
    Location:1202
    Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit

RNA

  1. XR_926031.2 RNA Sequence

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