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Cdk9 cyclin dependent kinase 9 [ Mus musculus (house mouse) ]

Gene ID: 107951, updated on 8-Feb-2024

Summary

Official Symbol
Cdk9provided by MGI
Official Full Name
cyclin dependent kinase 9provided by MGI
Primary source
MGI:MGI:1328368
See related
Ensembl:ENSMUSG00000009555 AllianceGenome:MGI:1328368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PITALRE
Summary
Enables several functions, including RNA polymerase II CTD heptapeptide repeat kinase activity; chromatin binding activity; and nucleic acid binding activity. Involved in positive regulation of histone H2B ubiquitination and positive regulation of histone phosphorylation. Located in nucleus. Part of cyclin/CDK positive transcription elongation factor complex. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human CDK9 (cyclin dependent kinase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 28.4), thymus adult (RPKM 26.4) and 28 other tissues See more
Orthologs
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Genomic context

See Cdk9 in Genome Data Viewer
Location:
2 B; 2 22.09 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32595794..32608098, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32705782..32712784, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene endoglin Neighboring gene predicted gene, 26236 Neighboring gene STARR-positive B cell enhancer ABC_E4436 Neighboring gene STARR-positive B cell enhancer ABC_E505 Neighboring gene folylpolyglutamyl synthetase Neighboring gene microRNA 8093 Neighboring gene STARR-seq mESC enhancer starr_04206 Neighboring gene STARR-positive B cell enhancer ABC_E8785 Neighboring gene STARR-positive B cell enhancer ABC_E7807 Neighboring gene microRNA 2861 Neighboring gene microRNA 3960 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32577778-32577887 Neighboring gene predicted gene, 33457 Neighboring gene STARR-positive B cell enhancer ABC_E3368 Neighboring gene SH2 domain containing 3C Neighboring gene RIKEN cDNA 6330409D20 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 7SK snRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleus localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription elongation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of P-TEFb complex ISO
Inferred from Sequence Orthology
more info
 
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin/CDK positive transcription elongation factor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cyclin/CDK positive transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin/CDK positive transcription elongation factor complex TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 9
Names
cell division protein kinase 9
cyclin dependent kinase 9 (CDC2-related kinase)
NP_570930.1
XP_011237303.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130860.3NP_570930.1  cyclin-dependent kinase 9

    See identical proteins and their annotated locations for NP_570930.1

    Status: VALIDATED

    Source sequence(s)
    AK143217, AL772271
    Consensus CDS
    CCDS15927.1
    UniProtKB/Swiss-Prot
    B0R020, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0, Q99J95
    Related
    ENSMUSP00000009699.10, ENSMUST00000009699.16
    Conserved Domains (1) summary
    cd07865
    Location:6315
    STKc_CDK9; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32595794..32608098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239001.2XP_011237303.1  cyclin-dependent kinase 9 isoform X1

    See identical proteins and their annotated locations for XP_011237303.1

    UniProtKB/Swiss-Prot
    Q99J95
    Conserved Domains (1) summary
    cl21453
    Location:1186
    PKc_like; Protein Kinases, catalytic domain