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ZNF268 zinc finger protein 268 [ Homo sapiens (human) ]

Gene ID: 10795, updated on 5-Jan-2022

Summary

Official Symbol
ZNF268provided by HGNC
Official Full Name
zinc finger protein 268provided by HGNC
Primary source
HGNC:HGNC:13061
See related
Ensembl:ENSG00000090612 MIM:604753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF3
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of NIK/NF-kappaB signaling; positive regulation of nitrogen compound metabolic process; and regulation of apoptotic process. Located in actin cytoskeleton; cytosol; and nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in thyroid (RPKM 5.9), kidney (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF268 in Genome Data Viewer
Location:
12q24.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (133181495..133214832)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133758081..133791418)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 891 Neighboring gene ribosomal protein L23a pseudogene 67 Neighboring gene zinc finger protein 10 Neighboring gene anomalous homeobox Neighboring gene RNA, U6 small nuclear 717, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ZNF10

Homology

Clone Names

  • MGC126498

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 268
Names
zinc finger protein 3
zinc finger protein HZF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165881.3NP_001159353.1  zinc finger protein 268 isoform a

    See identical proteins and their annotated locations for NP_001159353.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AC226150, AW138703, BC110542, KF455750
    Consensus CDS
    CCDS45012.1
    UniProtKB/Swiss-Prot
    Q14587
    UniProtKB/TrEMBL
    Q2TB61
    Related
    ENSP00000228289.5, ENST00000228289.9
    Conserved Domains (6) summary
    smart00349
    Location:81141
    KRAB; krueppel associated box
    COG5048
    Location:497910
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:558578
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:556578
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:81120
    KRAB; KRAB box
    pfam13465
    Location:710734
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001165882.3NP_001159354.1  zinc finger protein 268 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC026786, AC226150, AW138703, BC110542, CN255799, KF455750
    UniProtKB/TrEMBL
    Q2TB61
    Conserved Domains (6) summary
    smart00349
    Location:258
    KRAB; krueppel associated box
    COG5048
    Location:414827
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:475495
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:473495
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237
    KRAB; KRAB box
    pfam13465
    Location:627651
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001165883.2NP_001159355.1  zinc finger protein 268 isoform d

    See identical proteins and their annotated locations for NP_001159355.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two exons in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC026786, AC226150, AF317549, BC058548, KF455750
    Consensus CDS
    CCDS59240.1
    UniProtKB/Swiss-Prot
    Q14587
    Related
    ENSP00000467781.1, ENST00000539248.6
  4. NM_001165884.3NP_001159356.2  zinc finger protein 268 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks three alternate exons in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (e) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC226150, AF317549, AF432217, AW138703, KF455750
    Consensus CDS
    CCDS53854.1
    UniProtKB/Swiss-Prot
    Q14587
    UniProtKB/TrEMBL
    F5H1T2
    Related
    ENSP00000438941.1, ENST00000536899.6
  5. NM_001165885.2NP_001159357.1  zinc finger protein 268 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate exon in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (f) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC026786, AC226150, AF317549, DQ057356, KF455750
    Consensus CDS
    CCDS53851.1
    UniProtKB/Swiss-Prot
    Q14587
    UniProtKB/TrEMBL
    F5H7L3
    Related
    ENSP00000442446.2, ENST00000541211.6
  6. NM_001165886.2NP_001159358.1  zinc finger protein 268 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks two alternate exons in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (g) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC026786, AC226150, AF317549, DQ057357, KF455750
    Consensus CDS
    CCDS53853.1
    UniProtKB/Swiss-Prot
    Q14587
    UniProtKB/TrEMBL
    F5H670
    Related
    ENSP00000437858.1, ENST00000542711.6
  7. NM_001165887.2NP_001159359.1  zinc finger protein 268 isoform h

    See identical proteins and their annotated locations for NP_001159359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an alternate in-frame exon and contains an alternate coding exon, which causes a frameshift compared to variant 1. The resulting isoform (h) lacks an internal segment and has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC026786, AC226150, AF317549, DB079580, DQ057360, KF455750
    Consensus CDS
    CCDS53852.1
    UniProtKB/Swiss-Prot
    Q14587
    UniProtKB/TrEMBL
    K7EQP6
    Related
    ENSP00000467922.1, ENST00000592241.5
    Conserved Domains (1) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
  8. NM_003415.3NP_003406.1  zinc finger protein 268 isoform a

    See identical proteins and their annotated locations for NP_003406.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AC226150, AF317549, KF455750
    Consensus CDS
    CCDS45012.1
    UniProtKB/Swiss-Prot
    Q14587
    Related
    ENSP00000444412.3, ENST00000536435.7
    Conserved Domains (6) summary
    smart00349
    Location:81141
    KRAB; krueppel associated box
    COG5048
    Location:497910
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:558578
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:556578
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:81120
    KRAB; KRAB box
    pfam13465
    Location:710734
    zf-H2C2_2; Zinc-finger double domain
  9. NM_152943.3NP_694422.2  zinc finger protein 268 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate coding exon, which causes a frameshift compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC226150, AF317549, AF385187, KF455750
    Consensus CDS
    CCDS59239.1
    UniProtKB/Swiss-Prot
    Q14587
    UniProtKB/TrEMBL
    A0A075B6T9
    Related
    ENSP00000439539.2, ENST00000541009.6
    Conserved Domains (2) summary
    smart00349
    Location:81141
    KRAB; krueppel associated box
    pfam01352
    Location:81120
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    133181495..133214832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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