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Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 107934, updated on 12-May-2024

Summary

Official Symbol
Celsr3provided by MGI
Official Full Name
cadherin, EGF LAG seven-pass G-type receptor 3provided by MGI
Primary source
MGI:MGI:1858236
See related
Ensembl:ENSMUSG00000023473 AllianceGenome:MGI:1858236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fmi1; Adgrc3; flamingo; mKIAA0812
Summary
Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in dopaminergic neuron axon guidance; planar cell polarity pathway involved in axon guidance; and serotonergic neuron axon guidance. Acts upstream of or within several processes, including cilium assembly; generation of neurons; and regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; embryo ectoderm; epiblast; peripheral nervous system; and retina. Orthologous to human CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 20.1), CNS E18 (RPKM 16.6) and 6 other tissues See more
Orthologs
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Genomic context

See Celsr3 in Genome Data Viewer
Location:
9 F2; 9 59.63 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108703244..108730168)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108826023..108852969)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NCK interacting protein with SH3 domain Neighboring gene predicted gene, 35025 Neighboring gene STARR-positive B cell enhancer ABC_E5104 Neighboring gene solute carrier family 26, member 6 Neighboring gene transmembrane protein 89

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway, planar cell polarity pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cilium assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in dopaminergic neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within motor neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of protein localization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in serotonergic neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cadherin EGF LAG seven-pass G-type receptor 3
Names
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359572.1NP_001346501.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC168054
    Consensus CDS
    CCDS90664.1
    UniProtKB/TrEMBL
    A0A076N9U7, A0A1L1SUG9
    Related
    ENSMUSP00000150759.2, ENSMUST00000213524.3
    Conserved Domains (10) summary
    smart00303
    Location:24742527
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:646743
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:21172181
    HormR; Domain present in hormone receptors
    cd00054
    Location:17171748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:20672105
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:15081691
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:19942033
    Laminin_EGF; Laminin EGF domain
    pfam16489
    Location:22002448
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:25372561
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:25342787
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001359573.1NP_001346502.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC168054
    UniProtKB/TrEMBL
    A0A076N9U7
    Conserved Domains (10) summary
    smart00303
    Location:24742527
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:646743
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:21172181
    HormR; Domain present in hormone receptors
    cd00054
    Location:17171748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:20672105
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:15081691
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:19942033
    Laminin_EGF; Laminin EGF domain
    pfam16489
    Location:22002448
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:25372561
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:25342786
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. NM_080437.3NP_536685.2  cadherin EGF LAG seven-pass G-type receptor 3 isoform 3 precursor

    See identical proteins and their annotated locations for NP_536685.2

    Status: VALIDATED

    Source sequence(s)
    AC168054, AF427498, AI854184, CA328665
    UniProtKB/Swiss-Prot
    E9QLD7, Q91ZI0, Q9ESD0
    UniProtKB/TrEMBL
    A0A076N9U7
    Related
    ENSMUSP00000024238.6, ENSMUST00000024238.11
    Conserved Domains (9) summary
    smart00303
    Location:24672520
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:646743
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:21152174
    HormR; Domain present in hormone receptors
    cd00054
    Location:17151746
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:20652103
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:15061689
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00002
    Location:25272758
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam00053
    Location:19922031
    Laminin_EGF; Laminin EGF domain
    pfam16489
    Location:21942439
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108703244..108730168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511622.3XP_006511685.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X1

    UniProtKB/TrEMBL
    A0A076N9U7
    Conserved Domains (10) summary
    smart00303
    Location:24692522
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:646743
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:21172176
    HormR; Domain present in hormone receptors
    cd00054
    Location:17171748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:20672105
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:15081691
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd14964
    Location:25312556
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam00053
    Location:19942033
    Laminin_EGF; Laminin EGF domain
    pfam16489
    Location:21952443
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl28897
    Location:25292782
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_006511623.3XP_006511686.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X2

    UniProtKB/TrEMBL
    A0A076N9U7
    Conserved Domains (10) summary
    smart00303
    Location:24692522
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:646743
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:21172176
    HormR; Domain present in hormone receptors
    cd00054
    Location:17171748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:20672105
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:15081691
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd14964
    Location:25312556
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam00053
    Location:19942033
    Laminin_EGF; Laminin EGF domain
    pfam16489
    Location:21952443
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl28897
    Location:25292781
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_006511625.4XP_006511688.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X3

    UniProtKB/TrEMBL
    A0A076N9U7
    Conserved Domains (10) summary
    smart00303
    Location:24742527
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:646743
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:21172181
    HormR; Domain present in hormone receptors
    cd00054
    Location:17171748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:20672105
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:15081691
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd14964
    Location:25362561
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam00053
    Location:19942033
    Laminin_EGF; Laminin EGF domain
    pfam16489
    Location:22002448
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl28897
    Location:25342724
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. XM_006511626.3XP_006511689.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X4

    Conserved Domains (6) summary
    cd11304
    Location:646743
    Cadherin_repeat; Cadherin tandem repeat domain
    PHA03307
    Location:9276
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00054
    Location:17171748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:20302053
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:15081691
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:19942033
    Laminin_EGF; Laminin EGF domain

RNA

  1. XR_004935302.1 RNA Sequence

  2. XR_001778786.3 RNA Sequence

  3. XR_379754.3 RNA Sequence