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VAMP5 vesicle associated membrane protein 5 [ Homo sapiens (human) ]

Gene ID: 10791, updated on 7-Jun-2020

Summary

Official Symbol
VAMP5provided by HGNC
Official Full Name
vesicle associated membrane protein 5provided by HGNC
Primary source
HGNC:HGNC:12646
See related
Ensembl:ENSG00000168899 MIM:607029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 45.4), fat (RPKM 40.5) and 24 other tissues See more
Orthologs

Genomic context

See VAMP5 in Genome Data Viewer
Location:
2p11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (85584431..85593406)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85811531..85820511)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 126, pseudogene Neighboring gene vesicle associated membrane protein 8 Neighboring gene ring finger protein 181 Neighboring gene transmembrane protein 150A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
muscle organ development TAS
Traceable Author Statement
more info
PubMed 
skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
integral component of organelle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
 
late endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
vesicle-associated membrane protein 5
Names
VAMP-5
myobrevin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006634.3NP_006625.1  vesicle-associated membrane protein 5

    See identical proteins and their annotated locations for NP_006625.1

    Status: REVIEWED

    Source sequence(s)
    AC016753, BC017891
    Consensus CDS
    CCDS1980.1
    UniProtKB/Swiss-Prot
    O95183
    UniProtKB/TrEMBL
    Q6FG93
    Related
    ENSP00000305647.4, ENST00000306384.5
    Conserved Domains (1) summary
    cd15872
    Location:370
    R-SNARE_VAMP5; SNARE motif of VAMP5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    85584431..85593406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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