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VAMP5 vesicle associated membrane protein 5 [ Homo sapiens (human) ]

Gene ID: 10791, updated on 5-Jul-2025
Official Symbol
VAMP5provided by HGNC
Official Full Name
vesicle associated membrane protein 5provided by HGNC
Primary source
HGNC:HGNC:12646
See related
Ensembl:ENSG00000168899 MIM:607029; AllianceGenome:HGNC:12646
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 45.4), fat (RPKM 40.5) and 24 other tissues See more
Orthologs
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See VAMP5 in Genome Data Viewer
Location:
2p11.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85584431..85593406)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85586491..85595466)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85811554..85820529)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 126, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16133 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85806777-85807430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85807431-85808085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85808086-85808739 Neighboring gene vesicle associated membrane protein 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85811231-85812186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85819815-85820316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85820317-85820816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11704 Neighboring gene ring finger protein 181 Neighboring gene transmembrane protein 150A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11705 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11706

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within Golgi to plasma membrane protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle organ development IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle organ development TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in intercalated disc IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in organelle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in organelle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
vesicle-associated membrane protein 5
Names
VAMP-5
myobrevin

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006634.3NP_006625.1  vesicle-associated membrane protein 5

    See identical proteins and their annotated locations for NP_006625.1

    Status: REVIEWED

    Source sequence(s)
    AC016753, BC017891
    Consensus CDS
    CCDS1980.1
    UniProtKB/Swiss-Prot
    O95183, Q9P0T2
    UniProtKB/TrEMBL
    Q6FG93
    Related
    ENSP00000305647.4, ENST00000306384.5
    Conserved Domains (1) summary
    cd15872
    Location:370
    R-SNARE_VAMP5; SNARE motif of VAMP5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    85584431..85593406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    85586491..85595466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)