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Mgat5 mannoside acetylglucosaminyltransferase 5 [ Mus musculus (house mouse) ]

Gene ID: 107895, updated on 18-Sep-2024

Summary

Official Symbol
Mgat5provided by MGI
Official Full Name
mannoside acetylglucosaminyltransferase 5provided by MGI
Primary source
MGI:MGI:894701
See related
Ensembl:ENSMUSG00000036155 AllianceGenome:MGI:894701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GlcNAc-TV; 4930471A21Rik; 5330407H02Rik
Summary
Enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within protein N-linked glycosylation. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; brain; integumental system; sensory organ; and urinary system. Orthologous to human MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 9.9), frontal lobe adult (RPKM 9.4) and 27 other tissues See more
Orthologs
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Genomic context

See Mgat5 in Genome Data Viewer
Location:
1 E3; 1 55.71 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (127132450..127413760)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (127204919..127488334)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41945 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02119 Neighboring gene STARR-seq mESC enhancer starr_02121 Neighboring gene STARR-seq mESC enhancer starr_02130 Neighboring gene predicted gene 8451 Neighboring gene predicted gene, 51747 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129277748-129278049 Neighboring gene predicted gene, 23370 Neighboring gene STARR-seq mESC enhancer starr_02135 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129321878-129322179 Neighboring gene predicted gene, 23734 Neighboring gene predicted gene, 51746 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129355594-129355895 Neighboring gene STARR-positive B cell enhancer ABC_E3299 Neighboring gene predicted gene, 41947 Neighboring gene STARR-seq mESC enhancer starr_02141 Neighboring gene STARR-positive B cell enhancer ABC_E3300 Neighboring gene transmembrane protein 163 Neighboring gene VISTA enhancer mm790 Neighboring gene STARR-positive B cell enhancer ABC_E9476 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129576446-129576747 Neighboring gene STARR-seq mESC enhancer starr_02145 Neighboring gene predicted gene, 35993 Neighboring gene amino carboxymuconate semialdehyde decarboxylase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
Names
GNT-V
N-acetylglucosaminyl-transferase V
alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase
beta1,6N-acetylglucosaminyltransferase V
glcNAc-T V
NP_660110.2
XP_006529118.1
XP_006529119.1
XP_006529120.1
XP_030110888.1
XP_036022125.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145128.3NP_660110.2  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

    See identical proteins and their annotated locations for NP_660110.2

    Status: VALIDATED

    Source sequence(s)
    AK030402, BC125533, BY752687
    Consensus CDS
    CCDS15245.1
    UniProtKB/Swiss-Prot
    Q8R4G6
    UniProtKB/TrEMBL
    Q059T5
    Related
    ENSMUSP00000038359.5, ENSMUST00000038361.11
    Conserved Domains (2) summary
    pfam15027
    Location:7137
    DUF4525; Domain of unknown function (DUF4525)
    pfam15024
    Location:171725
    Glyco_transf_18; Glycosyltransferase family 18

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    127132450..127413760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529056.5XP_006529119.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A isoform X1

    See identical proteins and their annotated locations for XP_006529119.1

    UniProtKB/Swiss-Prot
    Q8R4G6
    UniProtKB/TrEMBL
    Q059T5
    Conserved Domains (2) summary
    pfam15027
    Location:7137
    DUF4525; Domain of unknown function (DUF4525)
    pfam15024
    Location:171725
    Glyco_transf_18; Glycosyltransferase family 18
  2. XM_006529055.5XP_006529118.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A isoform X1

    See identical proteins and their annotated locations for XP_006529118.1

    UniProtKB/Swiss-Prot
    Q8R4G6
    UniProtKB/TrEMBL
    Q059T5
    Conserved Domains (2) summary
    pfam15027
    Location:7137
    DUF4525; Domain of unknown function (DUF4525)
    pfam15024
    Location:171725
    Glyco_transf_18; Glycosyltransferase family 18
  3. XM_030255028.2XP_030110888.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A isoform X1

    UniProtKB/Swiss-Prot
    Q8R4G6
    UniProtKB/TrEMBL
    Q059T5
    Conserved Domains (2) summary
    pfam15027
    Location:7137
    DUF4525; Domain of unknown function (DUF4525)
    pfam15024
    Location:171725
    Glyco_transf_18; Glycosyltransferase family 18
  4. XM_006529057.5XP_006529120.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A isoform X1

    See identical proteins and their annotated locations for XP_006529120.1

    UniProtKB/Swiss-Prot
    Q8R4G6
    UniProtKB/TrEMBL
    Q059T5
    Conserved Domains (2) summary
    pfam15027
    Location:7137
    DUF4525; Domain of unknown function (DUF4525)
    pfam15024
    Location:171725
    Glyco_transf_18; Glycosyltransferase family 18
  5. XM_036166232.1XP_036022125.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A isoform X1

    UniProtKB/Swiss-Prot
    Q8R4G6
    UniProtKB/TrEMBL
    Q059T5
    Related
    ENSMUSP00000129166.2, ENSMUST00000171405.2
    Conserved Domains (2) summary
    pfam15027
    Location:7137
    DUF4525; Domain of unknown function (DUF4525)
    pfam15024
    Location:171725
    Glyco_transf_18; Glycosyltransferase family 18