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Gcm2 glial cells missing homolog 2 [ Mus musculus (house mouse) ]

Gene ID: 107889, updated on 12-May-2024

Summary

Official Symbol
Gcm2provided by MGI
Official Full Name
glial cells missing homolog 2provided by MGI
Primary source
MGI:MGI:1861438
See related
Ensembl:ENSMUSG00000021362 AllianceGenome:MGI:1861438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcm1; Gcm-rs1; Gcm1-rs2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cellular response to organic substance; negative regulation of apoptotic process; and parathyroid gland development. Located in nucleus. Is expressed in several structures, including branchial pouch; central nervous system; genitourinary system; gut; and retina. Used to study hypoparathyroidism. Human ortholog(s) of this gene implicated in familial isolated hypoparathyroidism and hyperparathyroidism. Orthologous to human GCM2 (glial cells missing transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Gcm2 in Genome Data Viewer
Location:
13 A3.3; 13 20.31 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (41254903..41264511, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (41101427..41111035, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9874 Neighboring gene transmembrane protein 14C Neighboring gene male germ cell-associated kinase Neighboring gene synaptonemal complex protein 2-like Neighboring gene STARR-seq mESC enhancer starr_34300 Neighboring gene ELOVL fatty acid elongase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC130289, MGC130290

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glandular epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gliogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in intracellular phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular phosphate ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within parathyroid gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in parathyroid gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in parathyroid gland development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
chorion-specific transcription factor GCMb
Names
GCM motif protein 2
mGCMb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008104.2NP_032130.2  chorion-specific transcription factor GCMb

    See identical proteins and their annotated locations for NP_032130.2

    Status: VALIDATED

    Source sequence(s)
    AC158538, AF081556, BG070860
    Consensus CDS
    CCDS26472.1
    UniProtKB/Swiss-Prot
    O09102, Q2TB03, Q9QWX7, Q9Z289
    UniProtKB/TrEMBL
    A0A0R4J021
    Related
    ENSMUSP00000021791.7, ENSMUST00000021791.8
    Conserved Domains (1) summary
    pfam03615
    Location:35172
    GCM; GCM motif protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    41254903..41264511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315354.1XP_017170843.1  chorion-specific transcription factor GCMb isoform X1

    UniProtKB/TrEMBL
    A0A286YD23
    Related
    ENSMUSP00000153244.2, ENSMUST00000225271.2
    Conserved Domains (1) summary
    pfam03615
    Location:35172
    GCM; GCM motif protein