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Cth cystathionase (cystathionine gamma-lyase) [ Mus musculus (house mouse) ]

Gene ID: 107869, updated on 3-Jun-2018
Official Symbol
Cthprovided by MGI
Official Full Name
cystathionase (cystathionine gamma-lyase)provided by MGI
Primary source
MGI:MGI:1339968
See related
Ensembl:ENSMUSG00000028179 Vega:OTTMUSG00000029713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CSE; Cys3; AI314617; BC019483; 0610010I13Rik
Expression
Biased expression in liver adult (RPKM 166.5), liver E18 (RPKM 68.3) and 7 other tissues See more
Orthologs
See Cth in Genome Data Viewer
Location:
3; 3 H4
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (157894248..157925077, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (157557212..157588027, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene 5550 Neighboring gene predicted gene 6520 Neighboring gene RIKEN cDNA 1810013D15 gene Neighboring gene ankyrin repeat domain 13c

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Clone Names

  • MGC28655

Gene Ontology Provided by MGI

Function Evidence Code Pubs
L-cysteine desulfhydrase activity IEA
Inferred from Electronic Annotation
more info
 
L-cystine L-cysteine-lyase (deaminating) IDA
Inferred from Direct Assay
more info
PubMed 
L-cystine L-cysteine-lyase (deaminating) IMP
Inferred from Mutant Phenotype
more info
PubMed 
L-cystine L-cysteine-lyase (deaminating) ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
cystathionine beta-lyase activity ISO
Inferred from Sequence Orthology
more info
 
cystathionine gamma-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cystathionine gamma-lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
cystathionine gamma-lyase activity ISO
Inferred from Sequence Orthology
more info
 
cystathionine gamma-synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
'de novo' L-methionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
cysteine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cysteine biosynthetic process via cystathionine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cysteine biosynthetic process via cystathionine ISO
Inferred from Sequence Orthology
more info
 
glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
homocysteine metabolic process ISO
Inferred from Sequence Orthology
more info
 
hydrogen sulfide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of aortic smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
protein sulfhydration IDA
Inferred from Direct Assay
more info
PubMed 
protein sulfhydration IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein sulfhydration ISO
Inferred from Sequence Orthology
more info
 
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine ISO
Inferred from Sequence Orthology
more info
 
transsulfuration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transsulfuration ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
cystathionine gamma-lyase
Names
cysteine-protein sulfhydrase
NP_666065.1
XP_006500878.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145953.2NP_666065.1  cystathionine gamma-lyase

    See identical proteins and their annotated locations for NP_666065.1

    Status: VALIDATED

    Source sequence(s)
    AY083352
    Consensus CDS
    CCDS51101.1
    UniProtKB/Swiss-Prot
    Q8VCN5
    Related
    ENSMUSP00000113672.1, OTTMUSP00000038207, ENSMUST00000118539.1, OTTMUST00000073720
    Conserved Domains (2) summary
    PRK08776
    Location:16396
    PRK08776; cystathionine gamma-synthase; Provisional
    pfam01053
    Location:18394
    Cys_Met_Meta_PP; Cys/Met metabolizm PLP-dependent enzyme

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    157894248..157925077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500815.2XP_006500878.1  cystathionine gamma-lyase isoform X1

    Conserved Domains (1) summary
    cl18945
    Location:18298
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
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