Usp9y ubiquitin specific peptidase 9, Y chromosome [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp9yprovided by MGI
Official Full Name: ubiquitin specific peptidase 9, Y chromosomeprovided by MGI
Primary source: MGI:MGI:1313274
See related: Ensembl:ENSMUSG00000069044 AllianceGenome:MGI:1313274
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dffry; Fafl2
Summary: Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in cell migration and protein deubiquitination. Predicted to be active in cytosol and nucleus. Is expressed in brain; lung; and testis. Human ortholog(s) of this gene implicated in Y-linked spermatogenic failure 2. Orthologous to human USP9Y (ubiquitin specific peptidase 9 Y-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: Y; Ypter

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	Y	NC_000087.8 (1298961..1459782, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	Y	NC_000087.7 (1298961..1459782, complement)

Chromosome Y - NC_000087.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variations in Usp9y and the number of CAG repeats in Sry are significantly associated with testes weight.
Title: Effect of the Y chromosome on testis weight in mice.
Selection is acting to maintain the amino acid sequence of both the X and the Y-linked genes.
Title: Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.

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General gene information

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Markers

mUsp9y (e-PCR)
- UniSTS:514598

Usp9y (e-PCR), detects polymorphism
- UniSTS:256413

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein deubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: ubiquitin specific peptidase 9, Y chromosome

Names: ubiquitin specific protease 9, Y chromosome

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_148943.2 → NP_683745.2 ubiquitin specific peptidase 9, Y chromosome

See identical proteins and their annotated locations for NP_683745.2

Status: VALIDATED

Source sequence(s)

AC145393, AC145592

Consensus CDS

CCDS30544.1

UniProtKB/TrEMBL

F8VPU6

Related

ENSMUSP00000088727.6, ENSMUST00000091188.7

Conserved Domains (2) summary

cd02659
Location:1557 → 1960

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:1559 → 1955

UCH; Ubiquitin carboxyl-terminal hydrolase