U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Thoc5 THO complex 5 [ Mus musculus (house mouse) ]

Gene ID: 107829, updated on 11-Apr-2024

Summary

Official Symbol
Thoc5provided by MGI
Official Full Name
THO complex 5provided by MGI
Primary source
MGI:MGI:1351333
See related
Ensembl:ENSMUSG00000034274 AllianceGenome:MGI:1351333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fmip; Sgk2; PK1.3; 1700060C24Rik; A430085L24Rik
Summary
Enables mRNA binding activity. Involved in primitive hemopoiesis. Acts upstream of or within several processes, including negative regulation of macrophage differentiation; regulation of mRNA export from nucleus; and regulation of stem cell division. Located in nucleus. Is expressed in early conceptus and inner cell mass. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human THOC5 (THO complex 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 28.1), CNS E14 (RPKM 23.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Thoc5 in Genome Data Viewer
Location:
11 A1; 11 3.09 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4845339..4878867)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4895283..4928867)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene peptidase M20 domain containing 2 pseudogene Neighboring gene nipsnap homolog 1 Neighboring gene microRNA 6918 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 35321 Neighboring gene STARR-seq mESC enhancer starr_28417 Neighboring gene neurofilament, heavy polypeptide Neighboring gene adaptor protein complex AP-1, beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E5205 Neighboring gene predicted gene, 24958

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC49541

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within blastocyst development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of macrophage differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in primitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of THO complex ISO
Inferred from Sequence Orthology
more info
 
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of THO complex part of transcription export complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
THO complex subunit 5 homolog
Names
Fms interacting protein
fms-interacting protein
serum/glucocorticoid regulated kinase 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418151.1NP_001405080.1  THO complex subunit 5 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645522
  2. NM_172438.4NP_766026.1  THO complex subunit 5 homolog isoform 1

    See identical proteins and their annotated locations for NP_766026.1

    Status: VALIDATED

    Source sequence(s)
    AL645522
    Consensus CDS
    CCDS24393.1
    UniProtKB/Swiss-Prot
    Q69ZU0, Q8BKT7, Q8CHR3
    UniProtKB/TrEMBL
    A0A0R4J0J6
    Related
    ENSMUSP00000045580.2, ENSMUST00000038237.8
    Conserved Domains (1) summary
    pfam09766
    Location:97452
    FimP; Fms-interacting protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4845339..4878867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)