Thoc5 THO complex 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Thoc5provided by MGI
Official Full Name: THO complex 5provided by MGI
Primary source: MGI:MGI:1351333
See related: Ensembl:ENSMUSG00000034274 AllianceGenome:MGI:1351333
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fmip; Sgk2; PK1.3; 1700060C24Rik; A430085L24Rik
Summary: Enables mRNA binding activity. Involved in primitive hemopoiesis. Acts upstream of or within several processes, including negative regulation of macrophage differentiation; regulation of mRNA export from nucleus; and regulation of stem cell division. Located in nucleus. Is expressed in early conceptus and inner cell mass. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human THOC5 (THO complex 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 28.1), CNS E14 (RPKM 23.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11; 11 A1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (4845283..4878867)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (4895283..4928867)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results imply that murine leukemia virus requires UAP56, THOC5 and THOC7, in addition to NXF1, for nuclear export of viral transcripts.
Title: Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts.
THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier.
Title: THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier.
Regulation of immediate-early gene response by THOC5, a member of mRNA export complex contributes to the M-CSF-induced macrophage differentiation.
Title: Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation.
THOC5 may be required for mRNA export under stress and/or upon signaling-induced conditions
Title: Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts.
THOC5/Fms interacting protein is an essential element in the maintenance of hematopoiesis, and depletion of THOC5/Fms interacting protein causes the down-regulation of THOC1, which may contribute to altered THO complex function and cell death
Title: THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.
Wild-type FMIP and FMIPSS5,6AA inhibited M-CSF-mediated survival signaling, while FMIPSS5,6EE-expressing cells survived and differentiated into macrophages more efficiently than wild-type cells in the presence of M-CSF or TPA
Title: The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation.
FMIP influences the differentiation of C/EBP alpha gene during adipocyte differentiation of multipotent C2C12 cells.
Title: FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Thoc5 gene: The Thoc5 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 485 organisms have orthologs with human gene Thoc5
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables mRNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blastocyst development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA damage checkpoint	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of macrophage differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription, elongation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of DNA-templated transcription, elongation	ISO Inferred from Sequence Orthology more info
involved_in primitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in viral mRNA export from host cell nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of THO complex	ISO Inferred from Sequence Orthology more info
part_of THO complex part of transcription export complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of THO complex part of transcription export complex	ISO Inferred from Sequence Orthology more info
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription export complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: THO complex subunit 5 homolog

Names: Fms interacting protein; fms-interacting protein; serum/glucocorticoid regulated kinase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418151.1 → NP_001405080.1 THO complex subunit 5 homolog isoform 2

Status: VALIDATED

Source sequence(s)

AL645522
NM_172438.4 → NP_766026.1 THO complex subunit 5 homolog isoform 1

See identical proteins and their annotated locations for NP_766026.1

Status: VALIDATED

Source sequence(s)

AL645522

Consensus CDS

CCDS24393.1

UniProtKB/Swiss-Prot

Q8BKT7

UniProtKB/TrEMBL

A0A0R4J0J6

Related

ENSMUSP00000045580.2, ENSMUST00000038237.8

Conserved Domains (1) summary

pfam09766
Location:97 → 452

FimP; Fms-interacting protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

4845283..4878867

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514448.2 → XP_006514511.2 THO complex subunit 5 homolog isoform X1

Conserved Domains (1) summary

pfam09766
Location:97 → 464

FimP; Fms-interacting protein