Format

Send to:

Choose Destination

ZNF274 zinc finger protein 274 [ Homo sapiens (human) ]

Gene ID: 10782, updated on 12-Oct-2019

Summary

Official Symbol
ZNF274provided by HGNC
Official Full Name
zinc finger protein 274provided by HGNC
Primary source
HGNC:HGNC:13068
See related
Ensembl:ENSG00000171606 MIM:605467
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZF2; HFB101; ZSCAN51; ZKSCAN19
Summary
This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 9.7), ovary (RPKM 7.7) and 25 other tissues See more
Orthologs

Genomic context

See ZNF274 in Genome Data Viewer
Location:
19q13.43
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (58182989..58213562)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58694356..58724928)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 18 Neighboring gene zinc finger protein 329 Neighboring gene uncharacterized LOC105372479 Neighboring gene ribosomal protein S15a pseudogene 36 Neighboring gene zinc finger protein 436 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    p75(NTR)-mediated signaling, organism-specific biosystem
    p75(NTR)-mediated signaling

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37843, DKFZp686K08243

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
regulation of histone H3-K9 trimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neurotrophin receptor-interacting factor homolog
Names
KRAB zinc finger protein HFB101
zinc finger protein HFB101
zinc finger protein with KRAB and SCAN domains 19
zinc finger protein zfp2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278734.1NP_001265663.1  neurotrophin receptor-interacting factor homolog isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (ZNF274d) has an additional segment in the 5' region, which results in a downstream translation start codon, compared to variant ZNF274c. The resulting isoform (d) has a shorter N-terminus and contains only one KRAB A domain, compared to isoform c.
    Source sequence(s)
    BC009763, CA942346, DC362701, DC366107
    Consensus CDS
    CCDS74475.1
    UniProtKB/Swiss-Prot
    Q96GC6
    UniProtKB/TrEMBL
    A0A0A0MR47
    Related
    ENSP00000321209.5, ENST00000326804.8
    Conserved Domains (8) summary
    smart00431
    Location:115227
    SCAN; leucine rich region
    smart00349
    Location:245285
    KRAB; krueppel associated box
    COG5048
    Location:347599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:549571
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:245284
    KRAB; KRAB box
    pfam02023
    Location:115203
    SCAN; SCAN domain
    pfam13465
    Location:563588
    zf-H2C2_2; Zinc-finger double domain
  2. NM_016324.3NP_057408.2  neurotrophin receptor-interacting factor homolog isoform b

    See identical proteins and their annotated locations for NP_057408.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (ZNF274b) lacks three consecutive exons in the 5' region, which results in a downstream translation start codon, compared to variant ZNF274c. The resulting isoform (b) has a shorter N-terminus and contains only one KRAB A domain, compared to isoform c.
    Source sequence(s)
    AK222855, BC009763, CA942346, DC366107
    Consensus CDS
    CCDS74476.1
    UniProtKB/Swiss-Prot
    Q96GC6
    Related
    ENSP00000409872.3, ENST00000424679.6
    Conserved Domains (8) summary
    smart00431
    Location:52164
    SCAN; leucine rich region
    smart00349
    Location:182222
    KRAB; krueppel associated box
    COG5048
    Location:284536
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460480
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:486508
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:182221
    KRAB; KRAB box
    pfam02023
    Location:52140
    SCAN; SCAN domain
    pfam13465
    Location:500525
    zf-H2C2_2; Zinc-finger double domain
  3. NM_016325.3NP_057409.1  neurotrophin receptor-interacting factor homolog isoform a

    See identical proteins and their annotated locations for NP_057409.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (ZNF274a) lacks one in-frame coding exon, compared to variant ZNF274c. The resulting isoform (a) lacks an internal segment, compared to isoform c. Like isoform c, isoform a contains two KRAB A domains.
    Source sequence(s)
    AB029150, CA942346, DC366107
    Consensus CDS
    CCDS74474.1
    UniProtKB/Swiss-Prot
    Q96GC6
    Related
    ENSP00000321187.5, ENST00000345813.7
    Conserved Domains (8) summary
    smart00431
    Location:125237
    SCAN; leucine rich region
    smart00349
    Location:255295
    KRAB; krueppel associated box
    COG5048
    Location:357612
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:533553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:559581
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam02023
    Location:125213
    SCAN; SCAN domain
    pfam13465
    Location:573598
    zf-H2C2_2; Zinc-finger double domain
  4. NM_133502.3NP_598009.1  neurotrophin receptor-interacting factor homolog isoform c

    See identical proteins and their annotated locations for NP_598009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (ZNF274c) encodes the longest isoform (c). Isoform c contains two KRAB A domains.
    Source sequence(s)
    AB029150, BC009763, CA942346, DC366107
    Consensus CDS
    CCDS74473.1
    UniProtKB/Swiss-Prot
    Q96GC6
    Related
    ENSP00000484810.1, ENST00000617501.5
    Conserved Domains (8) summary
    smart00431
    Location:157269
    SCAN; leucine rich region
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:389644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:565585
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:591613
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam02023
    Location:157245
    SCAN; SCAN domain
    pfam13465
    Location:605630
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    58182989..58213562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026174.1XP_016881663.1  neurotrophin receptor-interacting factor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q96GC6
    Conserved Domains (8) summary
    smart00431
    Location:52164
    SCAN; leucine rich region
    smart00349
    Location:182222
    KRAB; krueppel associated box
    COG5048
    Location:284536
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460480
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:486508
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:182221
    KRAB; KRAB box
    pfam02023
    Location:52140
    SCAN; SCAN domain
    pfam13465
    Location:500525
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011526327.1XP_011524629.1  neurotrophin receptor-interacting factor homolog isoform X1

    See identical proteins and their annotated locations for XP_011524629.1

    UniProtKB/Swiss-Prot
    Q96GC6
    Conserved Domains (8) summary
    smart00431
    Location:52164
    SCAN; leucine rich region
    smart00349
    Location:182222
    KRAB; krueppel associated box
    COG5048
    Location:284536
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460480
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:486508
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:182221
    KRAB; KRAB box
    pfam02023
    Location:52140
    SCAN; SCAN domain
    pfam13465
    Location:500525
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017026175.1XP_016881664.1  neurotrophin receptor-interacting factor homolog isoform X3

  4. XM_011526328.2XP_011524630.1  neurotrophin receptor-interacting factor homolog isoform X2

    See identical proteins and their annotated locations for XP_011524630.1

    Conserved Domains (3) summary
    sd00017
    Location:250270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:276298
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:290315
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_001753588.2 RNA Sequence

  2. XR_001753589.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001278735.1: Suppressed sequence

    Description
    NM_001278735.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center