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ZNF266 zinc finger protein 266 [ Homo sapiens (human) ]

Gene ID: 10781, updated on 12-Oct-2019

Summary

Official Symbol
ZNF266provided by HGNC
Official Full Name
zinc finger protein 266provided by HGNC
Primary source
HGNC:HGNC:13059
See related
Ensembl:ENSG00000174652 MIM:604751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF1
Summary
This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]
Expression
Ubiquitous expression in spleen (RPKM 14.7), lymph node (RPKM 12.7) and 25 other tissues See more
Orthologs

Genomic context

See ZNF266 in Genome Data Viewer
Location:
19p13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (9412426..9435578, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9523102..9546254, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF559-ZNF177 readthrough Neighboring gene zinc finger protein 177 Neighboring gene uncharacterized LOC112268250 Neighboring gene endogenous retrovirus group K member 8 Gag polyprotein-like Neighboring gene zinc finger protein 560 Neighboring gene uncharacterized LOC105372268 Neighboring gene actin beta pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 266
Names
zinc finger protein 1
zinc finger protein HZF1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271314.1NP_001258243.1  zinc finger protein 266 isoform 1

    See identical proteins and their annotated locations for NP_001258243.1

    Status: REVIEWED

    Source sequence(s)
    AC011451, AL833503, CN484252, DA735170
    Consensus CDS
    CCDS12213.1
    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Related
    ENSP00000467151.1, ENST00000588933.5
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:128
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  2. NM_001370374.1NP_001357303.1  zinc finger protein 266 isforom 2

    Status: REVIEWED

    Source sequence(s)
    AC011451
    Related
    ENSP00000466714.2, ENST00000592904.6
  3. NM_001370375.1NP_001357304.1  zinc finger protein 266 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011451
  4. NM_001370376.1NP_001357305.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  5. NM_001370377.1NP_001357306.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  6. NM_001370378.1NP_001357307.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
    Related
    ENSP00000498589.1, ENST00000651268.1
  7. NM_001370379.1NP_001357308.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  8. NM_001370380.1NP_001357309.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
    Related
    ENSP00000468491.1, ENST00000588221.5
  9. NM_001370381.1NP_001357310.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  10. NM_001370382.1NP_001357311.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  11. NM_001370383.1NP_001357312.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  12. NM_001370384.1NP_001357313.1  zinc finger protein 266 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011451
  13. NM_001370385.1NP_001357314.1  zinc finger protein 266 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011451
  14. NM_001370386.1NP_001357315.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  15. NM_001370387.1NP_001357316.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  16. NM_001370388.1NP_001357317.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  17. NM_001370389.1NP_001357318.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  18. NM_001370390.1NP_001357319.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  19. NM_001370391.1NP_001357320.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  20. NM_001370392.1NP_001357321.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  21. NM_001370393.1NP_001357322.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  22. NM_001370394.1NP_001357323.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  23. NM_001370395.1NP_001357324.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  24. NM_001370396.1NP_001357325.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  25. NM_001370397.1NP_001357326.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  26. NM_001370398.1NP_001357327.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  27. NM_001370399.1NP_001357328.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  28. NM_001370400.1NP_001357329.1  zinc finger protein 266 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011451
  29. NM_006631.3NP_006622.2  zinc finger protein 266 isoform 1

    See identical proteins and their annotated locations for NP_006622.2

    Status: REVIEWED

    Source sequence(s)
    AC011451, AY376240, CN484252
    Consensus CDS
    CCDS12213.1
    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Related
    ENSP00000467315.1, ENST00000590306.5
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:128
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    9412426..9435578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026170.1XP_016881659.1  zinc finger protein 266 isoform X3

  2. XM_006722627.2XP_006722690.1  zinc finger protein 266 isoform X2

    See identical proteins and their annotated locations for XP_006722690.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:128
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  3. XM_011527650.1XP_011525952.1  zinc finger protein 266 isoform X2

    See identical proteins and their annotated locations for XP_011525952.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:128
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  4. XM_006722620.2XP_006722683.1  zinc finger protein 266 isoform X1

    See identical proteins and their annotated locations for XP_006722683.1

    Conserved Domains (6) summary
    smart00349
    Location:3995
    KRAB; krueppel associated box
    COG5048
    Location:277616
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:449469
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:199217
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3978
    KRAB; KRAB box
    pfam13465
    Location:549570
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017026168.1XP_016881657.1  zinc finger protein 266 isoform X3

  6. XM_017026173.2XP_016881662.1  zinc finger protein 266 isoform X4

    Conserved Domains (1) summary
    smart00349
    Location:3995
    KRAB; krueppel associated box
  7. XM_024451329.1XP_024307097.1  zinc finger protein 266 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:128
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  8. XM_017026156.1XP_016881645.1  zinc finger protein 266 isoform X2

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:128
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  9. XM_011527644.1XP_011525946.1  zinc finger protein 266 isoform X1

    See identical proteins and their annotated locations for XP_011525946.1

    Conserved Domains (6) summary
    smart00349
    Location:3995
    KRAB; krueppel associated box
    COG5048
    Location:277616
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:449469
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:199217
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3978
    KRAB; KRAB box
    pfam13465
    Location:549570
    zf-H2C2_2; Zinc-finger double domain
  10. XM_017026171.1XP_016881660.1  zinc finger protein 266 isoform X3

  11. XM_006722623.3XP_006722686.1  zinc finger protein 266 isoform X1

    See identical proteins and their annotated locations for XP_006722686.1

    Conserved Domains (6) summary
    smart00349
    Location:3995
    KRAB; krueppel associated box
    COG5048
    Location:277616
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:449469
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:199217
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3978
    KRAB; KRAB box
    pfam13465
    Location:549570
    zf-H2C2_2; Zinc-finger double domain
  12. XM_017026172.2XP_016881661.1  zinc finger protein 266 isoform X3

  13. XM_017026167.2XP_016881656.1  zinc finger protein 266 isoform X2

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:128
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  14. XM_005259716.4XP_005259773.1  zinc finger protein 266 isoform X2

    See identical proteins and their annotated locations for XP_005259773.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:128
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  15. XM_017026166.2XP_016881655.1  zinc finger protein 266 isoform X2

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:128
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  16. XM_017026164.2XP_016881653.1  zinc finger protein 266 isoform X2

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Related
    ENSP00000467403.1, ENST00000592292.5
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:128
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  17. XM_017026169.2XP_016881658.1  zinc finger protein 266 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198058.1: Suppressed sequence

    Description
    NM_198058.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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