Bmyc brain expressed myelocytomatosis oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bmycprovided by MGI
Official Full Name: brain expressed myelocytomatosis oncogeneprovided by MGI
Primary source: MGI:MGI:88184
See related: Ensembl:ENSMUSG00000049086 AllianceGenome:MGI:88184
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mycb; 2900002K07Rik
Summary: Enables molecular adaptor activity. Predicted to be involved in several processes, including ERK1 and ERK2 cascade; regulation of fibroblast proliferation; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of with a positive effect on negative regulation of gene expression via chromosomal CpG island methylation. Located in spindle. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and retina. [provided by Alliance of Genome Resources, Jun 2025]
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Genomic context

Location:: 2 A3; 2 17.82 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25596891..25597733)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25706879..25707721)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data from knockout mice suggest that Bmyc is a regulator of Myc (myelocytomatosis oncogene) in vivo and that overexpression of Myc in developing testis leads to increased apoptosis of spermatogenic cells.
Title: Loss of Bmyc results in increased apoptosis associated with upregulation of Myc expression in juvenile murine testis.
The results provide new insights into Myc N-terminal protein-protein interactions providing a model for Myc regulation through differential involvement of Myc homology boxes 1 and 2 (MBI and MBII) in the binding of Myc interacting proteins.
Title: B-myc: N-terminal recognition of myc binding proteins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

RH129186 (e-PCR)
- UniSTS:212494

NoName (e-PCR)
- UniSTS:224622

AW060705 (e-PCR)
- UniSTS:178588

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein B-Myc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.