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Bmyc brain expressed myelocytomatosis oncogene [ Mus musculus (house mouse) ]

Gene ID: 107771, updated on 11-Apr-2024

Summary

Official Symbol
Bmycprovided by MGI
Official Full Name
brain expressed myelocytomatosis oncogeneprovided by MGI
Primary source
MGI:MGI:88184
See related
Ensembl:ENSMUSG00000049086 AllianceGenome:MGI:88184
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mycb; 2900002K07Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of cell population proliferation and regulation of transcription by RNA polymerase II. Located in spindle. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and retina. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Bmyc in Genome Data Viewer
Location:
2 A3; 2 17.82 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25596891..25597733)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25706879..25707721)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene lipocalin 10 Neighboring gene odorant binding protein 2A Neighboring gene odorant binding protein 2B Neighboring gene predicted gene, 54106 Neighboring gene lipocalin 3

Genomic regions, transcripts, and products

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_positive_effect negative regulation of gene expression via chromosomal CpG island methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-DNA complex disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Myc-Max complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023326.2NP_075815.2  protein B-Myc

    See identical proteins and their annotated locations for NP_075815.2

    Status: PROVISIONAL

    Source sequence(s)
    BC060207
    Consensus CDS
    CCDS15789.1
    UniProtKB/Swiss-Prot
    Q6P8Z1, Q9D6E3
    UniProtKB/TrEMBL
    A0PJL6
    Related
    ENSMUSP00000097885.5, ENSMUST00000061483.9
    Conserved Domains (1) summary
    pfam01056
    Location:6162
    Myc_N; Myc amino-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25596891..25597733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)