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ARPP19 cAMP regulated phosphoprotein 19 [ Homo sapiens (human) ]

Gene ID: 10776, updated on 11-Sep-2019

Summary

Official Symbol
ARPP19provided by HGNC
Official Full Name
cAMP regulated phosphoprotein 19provided by HGNC
Primary source
HGNC:HGNC:16967
See related
Ensembl:ENSG00000128989 MIM:605487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ENSAL; ARPP16; ARPP-16; ARPP-19
Summary
The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]
Expression
Ubiquitous expression in brain (RPKM 79.8), thyroid (RPKM 29.3) and 24 other tissues See more
Orthologs

Genomic context

See ARPP19 in Genome Data Viewer
Location:
15q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (52547045..52569446, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52839384..52861436, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene myosin VC Neighboring gene uncharacterized LOC105370819 Neighboring gene myosin VA Neighboring gene eukaryotic translation elongation factor 1 beta 2 pseudogene 1 Neighboring gene family with sequence similarity 214 member A Neighboring gene uncharacterized LOC105370821 Neighboring gene one cut homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • MASTL Facilitates Mitotic Progression, organism-specific biosystem (from REACTOME)
    MASTL Facilitates Mitotic Progression, organism-specific biosystemThe activity of MASTL, also known as the Greatwall kinase (GWL), is necessary for the entry and progression of mitosis. MASTL is activated by phosphorylation of several key residues during mitotic en...
  • Mitotic Prophase, organism-specific biosystem (from REACTOME)
    Mitotic Prophase, organism-specific biosystemDuring prophase, the chromatin in the nucleus condenses, and the nucleolus disappears. Centrioles begin moving to the opposite poles or sides of the cell. Some of the fibers that extend from the cen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41622

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase 2A binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glucose import NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cAMP-regulated phosphoprotein 19
Names
cAMP-regulated phosphoprotein 19kDa
cyclic AMP phosphoprotein, 19 kD

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306191.1NP_001293120.1  cAMP-regulated phosphoprotein 19 isoform 1

    See identical proteins and their annotated locations for NP_001293120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode isoform 1.
    Source sequence(s)
    AC025917, AL833077, HY011638
    Consensus CDS
    CCDS76757.1
    UniProtKB/Swiss-Prot
    P56211
    UniProtKB/TrEMBL
    H3BMD8
    Related
    ENSP00000454341.1, ENST00000561971.1
    Conserved Domains (1) summary
    pfam04667
    Location:47122
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region
  2. NM_001306195.1NP_001293124.1  cAMP-regulated phosphoprotein 19 isoform 2

    See identical proteins and their annotated locations for NP_001293124.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the CDS. The encoded isoform (2) is shorter than isoform 1. Both variants 3 and 4 encode isoform 2.
    Source sequence(s)
    AC025917, AL833077, DA647638
    Consensus CDS
    CCDS32242.1
    UniProtKB/Swiss-Prot
    P56211
    UniProtKB/TrEMBL
    A0A024R5U3
    Related
    ENSP00000455625.1, ENST00000566423.5
    Conserved Domains (1) summary
    pfam04667
    Location:28103
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region
  3. NM_001306196.2NP_001293125.1  cAMP-regulated phosphoprotein 19 isoform 1

    See identical proteins and their annotated locations for NP_001293125.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC025917
    Consensus CDS
    CCDS76757.1
    UniProtKB/Swiss-Prot
    P56211
    UniProtKB/TrEMBL
    H3BMD8
    Related
    ENSP00000454612.1, ENST00000564163.5
    Conserved Domains (1) summary
    pfam04667
    Location:47122
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region
  4. NM_001330309.1NP_001317238.1  cAMP-regulated phosphoprotein 19 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' structure, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC025917, AK123616, AL833077
    Consensus CDS
    CCDS81883.1
    UniProtKB/Swiss-Prot
    P56211
    Related
    ENSP00000454234.1, ENST00000561650.5
    Conserved Domains (1) summary
    pfam04667
    Location:1287
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region
  5. NM_006628.6NP_006619.1  cAMP-regulated phosphoprotein 19 isoform 2

    See identical proteins and their annotated locations for NP_006619.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the CDS. The encoded isoform (2) is shorter than isoform 1. Both variants 3 and 4 encode isoform 2.
    Source sequence(s)
    AC025917
    Consensus CDS
    CCDS32242.1
    UniProtKB/Swiss-Prot
    P56211
    UniProtKB/TrEMBL
    A0A024R5U3
    Related
    ENSP00000249822.4, ENST00000249822.8
    Conserved Domains (1) summary
    pfam04667
    Location:28103
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    52547045..52569446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021870.2XP_016877359.1  cAMP-regulated phosphoprotein 19 isoform X1

    UniProtKB/Swiss-Prot
    P56211
    Related
    ENSP00000455986.1, ENST00000563277.5
    Conserved Domains (1) summary
    pfam04667
    Location:1287
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region
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