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POP4 POP4 homolog, ribonuclease P/MRP subunit [ Homo sapiens (human) ]

Gene ID: 10775, updated on 1-Jun-2020

Summary

Official Symbol
POP4provided by HGNC
Official Full Name
POP4 homolog, ribonuclease P/MRP subunitprovided by HGNC
Primary source
HGNC:HGNC:30081
See related
Ensembl:ENSG00000105171 MIM:606114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPP29
Summary
This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in testis (RPKM 7.0), lymph node (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See POP4 in Genome Data Viewer
Location:
19q12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (29606283..29617237)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (30097170..30108162)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC284395 Neighboring gene Sharpr-MPRA regulatory region 9443 Neighboring gene V-set and transmembrane domain containing 2B Neighboring gene uncharacterized LOC105372353 Neighboring gene pleckstrin homology and FYVE domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr downregulates POP4 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ribonuclease MRP activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease P RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease P RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ribonuclease P activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA 5'-leader removal IDA
Inferred from Direct Assay
more info
PubMed 
tRNA 5'-leader removal TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
multimeric ribonuclease P complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ribonuclease P protein subunit p29
Names
hPOP4
NP_006618.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006627.3NP_006618.1  ribonuclease P protein subunit p29

    See identical proteins and their annotated locations for NP_006618.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes processing of precursor 4.
    Source sequence(s)
    AC010505, BU727144, Y18863
    Consensus CDS
    CCDS12416.1
    UniProtKB/Swiss-Prot
    O95707
    Related
    ENSP00000465213.1, ENST00000585603.6
    Conserved Domains (1) summary
    pfam01868
    Location:128210
    UPF0086; Domain of unknown function UPF0086

RNA

  1. NR_027368.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010505, AK303791, BU727144
    Related
    ENST00000221770.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    29606283..29617237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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