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Rapgef1 Rap guanine nucleotide exchange factor (GEF) 1 [ Mus musculus (house mouse) ]

Gene ID: 107746, updated on 31-Jan-2019

Summary

Official Symbol
Rapgef1provided by MGI
Official Full Name
Rap guanine nucleotide exchange factor (GEF) 1provided by MGI
Primary source
MGI:MGI:104580
See related
Ensembl:ENSMUSG00000039844
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C3G; Grf2; 4932418O06Rik
Expression
Ubiquitous expression in thymus adult (RPKM 38.9), spleen adult (RPKM 34.8) and 28 other tissues See more
Orthologs

Genomic context

See Rapgef1 in Genome Data Viewer
Location:
2 B; 2 20.32 cM
Exon count:
28
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (29619720..29740364)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (29475240..29595883)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 27 Neighboring gene microRNA 133c Neighboring gene predicted gene, 30761 Neighboring gene predicted gene 13420 Neighboring gene predicted gene 13547 Neighboring gene TruB pseudouridine (psi) synthase family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Rap guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
SH3/SH2 adaptor activity TAS
Traceable Author Statement
more info
PubMed 
guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rap protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
activation of GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
nerve growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of cell junction assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
phagocytic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rap guanine nucleotide exchange factor 1
Names
guanine nucleotide releasing factor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039086.1NP_001034175.1  rap guanine nucleotide exchange factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001034175.1

    Status: VALIDATED

    Source sequence(s)
    AK077034, AK147470, AK147696
    Consensus CDS
    CCDS38092.1
    UniProtKB/TrEMBL
    Q3UGX8, Q3UHC1, Q8C5V7
    Related
    ENSMUSP00000088680.5, ENSMUST00000091146.11
    Conserved Domains (2) summary
    smart00147
    Location:9771206
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:829970
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  2. NM_001039087.1NP_001034176.1  rap guanine nucleotide exchange factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001034176.1

    Status: VALIDATED

    Source sequence(s)
    AK077034, AK147468
    Consensus CDS
    CCDS38091.1
    UniProtKB/TrEMBL
    Q3UHC1, Q8C5V7
    Related
    ENSMUSP00000092703.4, ENSMUST00000095087.10
    Conserved Domains (2) summary
    smart00147
    Location:9831212
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:835976
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  3. NM_001362702.1NP_001349631.1  rap guanine nucleotide exchange factor 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK077034, AK147468, BC129881
    Conserved Domains (4) summary
    smart00147
    Location:9441173
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:796937
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cl26464
    Location:188298
    Atrophin-1; Atrophin-1 family
    cl27601
    Location:663778
    Pectinesterase; Pectinesterase
  4. NM_054050.2NP_473391.1  rap guanine nucleotide exchange factor 1 isoform 3

    See identical proteins and their annotated locations for NP_473391.1

    Status: VALIDATED

    Source sequence(s)
    AF348669, AK077034, AK147470
    Consensus CDS
    CCDS15854.1
    UniProtKB/TrEMBL
    Q3UHC1, Q8C5V7, Q91ZZ2
    Related
    ENSMUSP00000099936.4, ENSMUST00000102872.10
    Conserved Domains (2) summary
    smart00147
    Location:8451074
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:697838
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    29619720..29740364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497583.1XP_006497646.1  rap guanine nucleotide exchange factor 1 isoform X2

    Conserved Domains (2) summary
    smart00147
    Location:10151244
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:8671008
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  2. XM_006497588.1XP_006497651.1  rap guanine nucleotide exchange factor 1 isoform X7

    UniProtKB/TrEMBL
    A1L338
    Conserved Domains (4) summary
    smart00147
    Location:9441173
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:796937
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cl26464
    Location:188298
    Atrophin-1; Atrophin-1 family
    cl27601
    Location:663778
    Pectinesterase; Pectinesterase
  3. XM_006497582.3XP_006497645.1  rap guanine nucleotide exchange factor 1 isoform X1

    Conserved Domains (2) summary
    smart00147
    Location:10161245
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:8681009
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  4. XM_006497584.3XP_006497647.1  rap guanine nucleotide exchange factor 1 isoform X3

    Conserved Domains (2) summary
    smart00147
    Location:10151244
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:8671008
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  5. XM_006497587.3XP_006497650.1  rap guanine nucleotide exchange factor 1 isoform X6

    Conserved Domains (2) summary
    smart00147
    Location:9641193
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:816957
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  6. XM_006497585.3XP_006497648.1  rap guanine nucleotide exchange factor 1 isoform X4

    Conserved Domains (2) summary
    smart00147
    Location:9841213
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:836977
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  7. XM_006497586.3XP_006497649.1  rap guanine nucleotide exchange factor 1 isoform X5

    Conserved Domains (2) summary
    smart00147
    Location:9781207
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:830971
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  8. XM_006497589.3XP_006497652.1  rap guanine nucleotide exchange factor 1 isoform X8

    Conserved Domains (2) summary
    smart00147
    Location:8981127
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:750891
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  9. XM_006497590.3XP_006497653.1  rap guanine nucleotide exchange factor 1 isoform X9

    Conserved Domains (2) summary
    smart00147
    Location:8971126
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:749890
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  10. XM_006497592.3XP_006497655.1  rap guanine nucleotide exchange factor 1 isoform X10

    Conserved Domains (2) summary
    smart00147
    Location:8461075
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:698839
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
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