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ZBTB6 zinc finger and BTB domain containing 6 [ Homo sapiens (human) ]

Gene ID: 10773, updated on 11-Jun-2021

Summary

Official Symbol
ZBTB6provided by HGNC
Official Full Name
zinc finger and BTB domain containing 6provided by HGNC
Primary source
HGNC:HGNC:16764
See related
Ensembl:ENSG00000186130 MIM:605976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZID; ZNF482
Expression
Ubiquitous expression in lymph node (RPKM 5.7), thyroid (RPKM 5.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZBTB6 in Genome Data Viewer
Location:
9q33.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (122908056..122913323, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125670335..125675602, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 67 Neighboring gene ring finger and CCCH-type domains 2 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene zinc finger and BTB domain containing 26 Neighboring gene uncharacterized LOC105379839 Neighboring gene RAB GTPase activating protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Potential readthrough

Included gene: ZBTB26

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 6
Names
zinc finger protein 482
zinc finger protein with interaction domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006626.6NP_006617.1  zinc finger and BTB domain-containing protein 6

    See identical proteins and their annotated locations for NP_006617.1

    Status: VALIDATED

    Source sequence(s)
    BC037282, BU600946, BX390688, BX641237
    Consensus CDS
    CCDS6846.1
    UniProtKB/Swiss-Prot
    Q15916
    Related
    ENSP00000362763.3, ENST00000373659.4
    Conserved Domains (5) summary
    sd00017
    Location:328348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18197
    Location:8123
    BTB_POZ_ZBTB6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6)
    pfam00096
    Location:326348
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:340364
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:331401
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    122908056..122913323 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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