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SRSF10 serine and arginine rich splicing factor 10 [ Homo sapiens (human) ]

Gene ID: 10772, updated on 12-Oct-2019

Summary

Official Symbol
SRSF10provided by HGNC
Official Full Name
serine and arginine rich splicing factor 10provided by HGNC
Primary source
HGNC:HGNC:16713
See related
Ensembl:ENSG00000188529 MIM:605221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSSR; TASR; SRp38; TASR1; TASR2; FUSIP1; FUSIP2; SFRS13; SRrp40; SFRS13A; PPP1R149
Summary
This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in bone marrow (RPKM 28.7), lymph node (RPKM 12.7) and 25 other tissues See more
Orthologs

Genomic context

See SRSF10 in Genome Data Viewer
Location:
1p36.11
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (23964347..23980370, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24292935..24306953, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 378f Neighboring gene proline rich nuclear receptor coactivator 2 Neighboring gene uncharacterized LOC105378615 Neighboring gene ribosomal protein L36 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of serine/arginine-rich splicing factor 10 (SRSF10, FUSIP1) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30749, FLJ43846, DKFZp686H0644

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
RS domain binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
RNA splicing, via transesterification reactions IDA
Inferred from Direct Assay
more info
PubMed 
cytosolic transport IEA
Inferred from Electronic Annotation
more info
 
mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA splice site selection IDA
Inferred from Direct Assay
more info
PubMed 
mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
spliceosomal tri-snRNP complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
serine/arginine-rich splicing factor 10
Names
40 kDa SR-repressor protein
FUS interacting protein (serine-arginine rich) 1
FUS-interacting protein (serine-arginine rich) 2
SR splicing factor 10
TLS-associated SR protein
TLS-associated protein TASR
TLS-associated protein with SR repeats
TLS-associated protein with Ser-Arg repeats
TLS-associated serine-arginine protein 1
TLS-associated serine-arginine protein 2
neural-salient SR protein
protein phosphatase 1, regulatory subunit 149
serine-arginine repressor protein (40 kDa)
splicing factor SRp38
splicing factor, arginine/serine-rich 13
splicing factor, arginine/serine-rich 13A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191005.3NP_001177934.1  serine/arginine-rich splicing factor 10 isoform 3

    See identical proteins and their annotated locations for NP_001177934.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site, compared to variant 2. The encoded isoform (3) is shorter than isoform 2.
    Source sequence(s)
    AK001656, AL590609
    Consensus CDS
    CCDS53282.1
    UniProtKB/Swiss-Prot
    O75494
    Related
    ENSP00000344149.4, ENST00000343255.9
    Conserved Domains (1) summary
    cl17169
    Location:1093
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001191006.3NP_001177935.1  serine/arginine-rich splicing factor 10 isoform 4

    See identical proteins and their annotated locations for NP_001177935.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AK093226, AL590609, BC010074
    Consensus CDS
    CCDS53283.1
    UniProtKB/Swiss-Prot
    O75494
    Related
    ENSP00000363576.5, ENST00000374452.9
    Conserved Domains (1) summary
    cd12312
    Location:1093
    RRM_SRSF10_SRSF12; RNA recognition motif in serine/arginine-rich splicing factor SRSF10, SRSF12 and similar proteins
  3. NM_001191007.3NP_001177936.1  serine/arginine-rich splicing factor 10 isoform 5

    See identical proteins and their annotated locations for NP_001177936.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site and lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AK093226, AL590609, AY007101
    Consensus CDS
    CCDS53281.1
    UniProtKB/Swiss-Prot
    O75494
    Related
    ENSP00000388991.3, ENST00000453840.7
    Conserved Domains (1) summary
    cl17169
    Location:1093
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. NM_001191009.3NP_001177938.1  serine/arginine-rich splicing factor 10 isoform 6

    See identical proteins and their annotated locations for NP_001177938.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (6) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AK296175, AL590609, AY007101
    Consensus CDS
    CCDS53280.1
    UniProtKB/Swiss-Prot
    O75494
    Related
    ENSP00000419813.2, ENST00000484146.6
    Conserved Domains (1) summary
    cl17169
    Location:1093
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. NM_001300936.2NP_001287865.1  serine/arginine-rich splicing factor 10 isoform 8

    See identical proteins and their annotated locations for NP_001287865.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate in-frame splice site and lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (8) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AL590609
    Consensus CDS
    CCDS72728.1
    UniProtKB/TrEMBL
    Q5JRI1
    Related
    ENSP00000363577.3, ENST00000374453.7
    Conserved Domains (1) summary
    cl17169
    Location:1093
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. NM_001300937.2NP_001287866.1  serine/arginine-rich splicing factor 10 isoform 9

    See identical proteins and their annotated locations for NP_001287866.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (9) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AL590609
    Conserved Domains (1) summary
    cl17169
    Location:1093
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. NM_006625.6NP_006616.1  serine/arginine-rich splicing factor 10 isoform 1

    See identical proteins and their annotated locations for NP_006616.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (1) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AF419331, AL590609
    Consensus CDS
    CCDS30629.1
    UniProtKB/Swiss-Prot
    O75494
    Related
    ENSP00000342913.5, ENST00000344989.10
    Conserved Domains (2) summary
    COG0724
    Location:6174
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:1093
    RRM_SF; RNA recognition motif (RRM) superfamily
  8. NM_054016.4NP_473357.1  serine/arginine-rich splicing factor 10 isoform 2

    See identical proteins and their annotated locations for NP_473357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AK093226, AL590609, BC005039
    Consensus CDS
    CCDS30630.1
    UniProtKB/Swiss-Prot
    O75494
    UniProtKB/TrEMBL
    A0A0S2Z504
    Related
    ENSP00000420195.1, ENST00000492112.3
    Conserved Domains (1) summary
    cl17169
    Location:1093
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. NR_034035.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains multiple differences at both the 5' and 3' ends, compared to variant 2. This variant is represented as non-coding because the longest in-frame ORF does not meet RefSeq quality criteria.
    Source sequence(s)
    AK093226, AL590609, AY007101

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    23964347..23980370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000102.2XP_016855591.1  serine/arginine-rich splicing factor 10 isoform X1

    UniProtKB/TrEMBL
    B3KNY6
  2. XM_017000101.2XP_016855590.1  serine/arginine-rich splicing factor 10 isoform X1

    UniProtKB/TrEMBL
    B3KNY6
  3. XM_017000100.2XP_016855589.1  serine/arginine-rich splicing factor 10 isoform X1

    UniProtKB/TrEMBL
    B3KNY6
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