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Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 [ Mus musculus (house mouse) ]

Gene ID: 107652, updated on 14-Feb-2023

Summary

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Official Symbol
Uap1provided by MGI
Official Full Name
UDP-N-acetylglucosamine pyrophosphorylase 1provided by MGI
Primary source
MGI:MGI:1334459
See related
Ensembl:ENSMUSG00000026670 AllianceGenome:MGI:1334459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AgX; AGX1; AGX-1; AGX-2; SPAG2; ESTM38
Summary
Predicted to enable UDP-N-acetylglucosamine diphosphorylase activity; carbohydrate binding activity; and identical protein binding activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Orthologous to human UAP1 (UDP-N-acetylglucosamine pyrophosphorylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 10.9), colon adult (RPKM 10.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Uap1 in Genome Data Viewer
Location:
1; 1 H3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (169968792..170002533, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170141223..170174964, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110045C21 gene Neighboring gene hydroxysteroid (17-beta) dehydrogenase 7 Neighboring gene discoidin domain receptor family, member 2 Neighboring gene U2AF homology motif (UHM) kinase 1 Neighboring gene SH2 domain containing 1B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response. Yang S, et al. Mol Cell, 2023 Jan 19. PMID 36603579
  2. Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate. Cibi DM, et al. Elife, 2019 Jun 26. PMID 31241461, Free PMC Article
  3. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Yi J, et al. Hepatology, 2016 Nov. PMID 27531557, Free PMC Article
  4. The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Bebee TW, et al. Elife, 2015 Sep 15. PMID 26371508, Free PMC Article
  5. Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Eddleston J, et al. Genomics, 1999 Mar 1. PMID 10051400

See all (21) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response.
    Title: Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-N-acetylgalactosamine diphosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-N-acetylglucosamine diphosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables UDP-N-acetylglucosamine diphosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in UDP-N-acetylglucosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
UDP-N-acetylhexosamine pyrophosphorylase
Names
antigen X
sperm associated antigen 2
NP_001291974.1
NP_001291975.1
NP_598567.2
XP_006496669.4
XP_006496670.2
XP_006496671.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305045.1 → NP_001291974.1  UDP-N-acetylhexosamine pyrophosphorylase isoform 1

    See identical proteins and their annotated locations for NP_001291974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA646755, AC119893, AC123650, AI467637, AK036243, AK047566, AK049519, AK081690, BM947026
    Consensus CDS
    CCDS83632.1
    UniProtKB/Swiss-Prot
    Q91YN5
    UniProtKB/TrEMBL
    A0A8C6H1C3, Q3UHZ7
    Related
    ENSMUSP00000106983.4, ENSMUST00000111351.10
    Conserved Domains (1) summary
    cd04193
    Location:88 → 410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

  2. NM_001305046.1 → NP_001291975.1  UDP-N-acetylhexosamine pyrophosphorylase isoform 3

    See identical proteins and their annotated locations for NP_001291975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (3) is shorter compared to isoform 1.
    Source sequence(s)
    AA646755, AC119893, AC123650, AI467637, AK047566, AK049519, AK081690, BM947026
    Consensus CDS
    CCDS83631.1
    UniProtKB/Swiss-Prot
    Q91YN5
    UniProtKB/TrEMBL
    A0A0R4J1F6
    Related
    ENSMUSP00000106982.4, ENSMUST00000111350.10
    Conserved Domains (1) summary
    cd04193
    Location:88 → 410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

  3. NM_133806.5 → NP_598567.2  UDP-N-acetylhexosamine pyrophosphorylase isoform 2

    See identical proteins and their annotated locations for NP_598567.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AA646755, AC119893, AC123650, AI467637, AK047566, AK049519, AK081690, BM947026
    Consensus CDS
    CCDS15467.1
    UniProtKB/Swiss-Prot
    Q91YN5
    UniProtKB/TrEMBL
    A0A0R4J085
    Related
    ENSMUSP00000027981.8, ENSMUST00000027981.8
    Conserved Domains (1) summary
    cd04193
    Location:88 → 410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    169968792..170002533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496608.5 → XP_006496671.3  UDP-N-acetylhexosamine pyrophosphorylase isoform X3

    Conserved Domains (1) summary
    cd04193
    Location:112 → 434
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

  2. XM_006496607.5 → XP_006496670.2  UDP-N-acetylhexosamine pyrophosphorylase isoform X2

    UniProtKB/TrEMBL
    A0A0R4J085
    Conserved Domains (1) summary
    cd04193
    Location:88 → 410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

  3. XM_006496606.5 → XP_006496669.4  UDP-N-acetylhexosamine pyrophosphorylase isoform X1

    UniProtKB/TrEMBL
    A0A8C6H1C3, Q3UHZ7
    Conserved Domains (1) summary
    cd04193
    Location:88 → 410
    UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YN5.1 GenPept UniProtKB/Swiss-Prot:Q91YN5

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