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Pi4kb phosphatidylinositol 4-kinase beta [ Mus musculus (house mouse) ]

Gene ID: 107650, updated on 2-Apr-2024

Summary

Official Symbol
Pi4kbprovided by MGI
Official Full Name
phosphatidylinositol 4-kinase betaprovided by MGI
Primary source
MGI:MGI:1334433
See related
Ensembl:ENSMUSG00000038861 AllianceGenome:MGI:1334433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM41; Pik4cb; PI4Kbeta; PI4K-beta
Summary
Predicted to enable 1-phosphatidylinositol 4-kinase activity and 14-3-3 protein binding activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and phosphatidylinositol-mediated signaling. Predicted to be located in Golgi membrane; cytosol; and plasma membrane. Predicted to be active in cytoplasm and membrane. Is expressed in vertebral axis musculature. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 17.1), bladder adult (RPKM 16.1) and 28 other tissues See more
Orthologs
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Genomic context

See Pi4kb in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (94882042..94914248)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (94974731..95006937)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene selenium binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E231 Neighboring gene RIKEN cDNA B230398E01 gene Neighboring gene regulatory factor X, 5 (influences HLA class II expression) Neighboring gene STARR-seq mESC enhancer starr_08361 Neighboring gene STARR-positive B cell enhancer ABC_E652 Neighboring gene STARR-positive B cell enhancer ABC_E3449 Neighboring gene zinc finger protein 687 Neighboring gene microRNA 7013 Neighboring gene RIKEN cDNA 4930481B07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94820548-94820749 Neighboring gene STARR-positive B cell enhancer ABC_E4560 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 1-phosphatidylinositol 4-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in inner ear development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lysosome organization ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphatidylinositol 4-kinase beta
Names
phosphatidylinositol 4-kinase, catalytic, beta polypeptide
ptdIns 4-kinase beta
NP_001280644.1
NP_001280645.1
NP_780565.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293715.1NP_001280644.1  phosphatidylinositol 4-kinase beta isoform 1

    See identical proteins and their annotated locations for NP_001280644.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript (1) and encodes the longest isoform (1).
    Source sequence(s)
    AC087062
    Consensus CDS
    CCDS79978.1
    UniProtKB/Swiss-Prot
    Q14CH6, Q14DJ4, Q3TA58, Q68FH2, Q8BKC8, Q8C146
    UniProtKB/TrEMBL
    E9Q8A3
    Related
    ENSMUSP00000102872.3, ENSMUST00000107251.9
    Conserved Domains (1) summary
    cd05168
    Location:529816
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
  2. NM_001293716.1NP_001280645.1  phosphatidylinositol 4-kinase beta isoform 3

    See identical proteins and their annotated locations for NP_001280645.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC087062, AK157918, BC113781, BQ443265
    Consensus CDS
    CCDS79979.1
    UniProtKB/Swiss-Prot
    Q8BKC8
    Related
    ENSMUSP00000132150.2, ENSMUST00000167008.8
    Conserved Domains (1) summary
    cd05168
    Location:197484
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
  3. NM_175356.3NP_780565.2  phosphatidylinositol 4-kinase beta isoform 2

    See identical proteins and their annotated locations for NP_780565.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC087062, AK157918, BQ443265
    Consensus CDS
    CCDS17599.1
    UniProtKB/TrEMBL
    E9Q8A3
    Related
    ENSMUSP00000072134.6, ENSMUST00000072287.12
    Conserved Domains (1) summary
    cd05168
    Location:514801
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    94882042..94914248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)