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NES nestin [ Homo sapiens (human) ]

Gene ID: 10763, updated on 9-Sep-2018

Summary

Official Symbol
NESprovided by HGNC
Official Full Name
nestinprovided by HGNC
Primary source
HGNC:HGNC:7756
See related
Ensembl:ENSG00000132688 MIM:600915; Vega:OTTHUMG00000034299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Nbla00170
Summary
This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]
Expression
Broad expression in heart (RPKM 67.0), fat (RPKM 29.0) and 17 other tissues See more
Orthologs

Genomic context

See NES in Genome Data Viewer
Location:
1q23.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (156668763..156677397, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156638555..156647189, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371453 Neighboring gene brevican Neighboring gene VISTA enhancer hs1891 Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene interferon stimulated exonuclease gene 20 like 2 Neighboring gene ribosomal RNA adenine dimethylase domain containing 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
intermediate filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
molecular_function ND
No biological Data available
more info
 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
brain development ISS
Inferred from Sequence or Structural Similarity
more info
 
central nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
embryonic camera-type eye development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intermediate filament depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012300.1 RefSeqGene

    Range
    5001..13635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006617.1NP_006608.1  nestin

    See identical proteins and their annotated locations for NP_006608.1

    Status: REVIEWED

    Source sequence(s)
    AK025494, AL590666, BC051373
    Consensus CDS
    CCDS1151.1
    UniProtKB/Swiss-Prot
    P48681
    UniProtKB/TrEMBL
    Q9H6U9
    Related
    ENSP00000357206.3, OTTHUMP00000032198, ENST00000368223.3, OTTHUMT00000082844
    Conserved Domains (1) summary
    pfam00038
    Location:7312
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    156668763..156677397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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