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Dio3 deiodinase, iodothyronine type III [ Mus musculus (house mouse) ]

Gene ID: 107585, updated on 12-Mar-2023


Official Symbol
Dio3provided by MGI
Official Full Name
deiodinase, iodothyronine type IIIprovided by MGI
Primary source
See related
Ensembl:ENSMUSG00000075707 AllianceGenome:MGI:1306782
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
This is an intronless, imprinted gene that is preferentially expressed from the paternal allele in the mouse fetus. The encoded protein belongs to the iodothyronine deiodinase family, and catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5' triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. It is highly expressed in placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It thus plays a critical role in mammalian development by regulating circulating fetal thyroid hormone concentration. Knockout mice lacking this gene exhibit severe abnormalities related to development and reproduction. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2016]
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Genomic context

See Dio3 in Genome Data Viewer
12; 12 F1
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110245664..110247531)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110279230..110281097)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40576 Neighboring gene deiodinase, iodothyronine type III, opposite strand Neighboring gene microRNA 1247 Neighboring gene predicted gene 6988 Neighboring gene predicted gene 9063

Genomic regions, transcripts, and products


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information



Clone Names

  • MGC124117, MGC124118

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
enables thyroxine 5'-deiodinase activity IBA
Inferred from Biological aspect of Ancestor
more info
enables thyroxine 5'-deiodinase activity IMP
Inferred from Mutant Phenotype
more info
enables thyroxine 5-deiodinase activity IDA
Inferred from Direct Assay
more info
enables thyroxine 5-deiodinase activity ISO
Inferred from Sequence Orthology
more info
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
located_in membrane IEA
Inferred from Electronic Annotation
more info
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
thyroxine 5-deiodinase
type 3 DI
type III iodothyronine deiodinase
type-III 5'-deiodinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172119.2NP_742117.2  thyroxine 5-deiodinase

    See identical proteins and their annotated locations for NP_742117.2

    Status: REVIEWED

    Source sequence(s)
    AK140797, BX638763
    Consensus CDS
    Q3UKD2, Q91ZI8
    ENSMUSP00000133920.3, ENSMUST00000173014.3
    Conserved Domains (1) summary
    T4_deiodinase; Iodothyronine deiodinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000078.7 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)