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Nt5c3 5'-nucleotidase, cytosolic III [ Mus musculus (house mouse) ]

Gene ID: 107569, updated on 26-Sep-2022

Summary

Official Symbol
Nt5c3provided by MGI
Official Full Name
5'-nucleotidase, cytosolic IIIprovided by MGI
Primary source
MGI:MGI:1927186
See related
Ensembl:ENSMUSG00000029780 AllianceGenome:MGI:1927186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p36; Nt5y; PN-1; PN-I; PSN1; UMPH; P5N-1; Umph1; lupin; Nt5c3a; P5'N-1; Umph-1; cN-III; 1600024P05Rik; 2610206B05Rik; 3110004A18Rik
Summary
Enables 5'-nucleotidase activity. Involved in CMP catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; hemolymphoid system; liver; nervous system; and respiratory system. Orthologous to human NT5C3A (5'-nucleotidase, cytosolic IIIA). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 44.0), liver E14.5 (RPKM 35.0) and 18 other tissues See more
Orthologs
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Genomic context

See Nt5c3 in Genome Data Viewer
Location:
6; 6 B3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (56859385..56900993, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (56882400..56924008, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB (POZ) domain containing 2 Neighboring gene predicted gene 10209 Neighboring gene FK506 binding protein 9 Neighboring gene predicted gene, 53332 Neighboring gene vomeronasal 1 receptor 4 Neighboring gene vomeronasal 1 receptor 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 5'-nucleotidase activity ISO
Inferred from Sequence Orthology
more info
 
enables 5'-nucleotidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables XMP 5'-nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in CMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in UMP catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in adenosine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dCMP catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dTMP catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dUMP catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytosolic 5'-nucleotidase 3A
Names
5'-nucleotidase, pyrimidine
7-methylguanosine nucleotidase
7-methylguanosine phosphate-specific 5'-nucleotidase
cytosolic 5'-nucleotidase 3
cytosolic 5'-nucleotidase III
pyrimidine 5'-nucleotidase 1
uridine monophosphatase 1
NP_001239303.1
NP_001347892.1
NP_080280.3
XP_006505336.1
XP_006505337.1
XP_006505338.1
XP_006505339.1
XP_011239413.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252374.1NP_001239303.1  cytosolic 5'-nucleotidase 3A isoform 2

    See identical proteins and their annotated locations for NP_001239303.1

    Status: VALIDATED

    Source sequence(s)
    AC153616, AK160139, BX527194, CX734167
    Consensus CDS
    CCDS57424.1
    UniProtKB/Swiss-Prot
    Q9D020
    UniProtKB/TrEMBL
    A0A8C6G506
    Related
    ENSMUSP00000098918.3, ENSMUST00000101367.9
    Conserved Domains (1) summary
    cd07504
    Location:25297
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB
  2. NM_001360963.1NP_001347892.1  cytosolic 5'-nucleotidase 3A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153616, BX527194
    Consensus CDS
    CCDS57424.1
    UniProtKB/TrEMBL
    A0A8C6G506
    Conserved Domains (1) summary
    cd07504
    Location:25297
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB
  3. NM_026004.3NP_080280.3  cytosolic 5'-nucleotidase 3A isoform 1

    See identical proteins and their annotated locations for NP_080280.3

    Status: VALIDATED

    Source sequence(s)
    AK011525, AK011894, BX527194, BY261587
    Consensus CDS
    CCDS20171.1
    UniProtKB/Swiss-Prot
    Q9D020, Q9D0D9
    UniProtKB/TrEMBL
    A0A8C6G5S8
    Related
    ENSMUSP00000031793.6, ENSMUST00000031793.8
    Conserved Domains (1) summary
    cd07504
    Location:59331
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    56859385..56900993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241111.2XP_011239413.1  cytosolic 5'-nucleotidase 3A isoform X1

    See identical proteins and their annotated locations for XP_011239413.1

    UniProtKB/Swiss-Prot
    Q9D020
    UniProtKB/TrEMBL
    A0A8C6G506
    Conserved Domains (1) summary
    cd07504
    Location:25297
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB
  2. XM_006505275.3XP_006505338.1  cytosolic 5'-nucleotidase 3A isoform X3

    Conserved Domains (1) summary
    cd07504
    Location:14286
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB
  3. XM_006505274.3XP_006505337.1  cytosolic 5'-nucleotidase 3A isoform X2

    Conserved Domains (1) summary
    cd07504
    Location:20292
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB
  4. XM_006505273.3XP_006505336.1  cytosolic 5'-nucleotidase 3A isoform X1

    See identical proteins and their annotated locations for XP_006505336.1

    UniProtKB/Swiss-Prot
    Q9D020
    UniProtKB/TrEMBL
    A0A8C6G506
    Conserved Domains (1) summary
    cd07504
    Location:25297
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB
  5. XM_006505276.5XP_006505339.1  cytosolic 5'-nucleotidase 3A isoform X4

    Conserved Domains (1) summary
    cd07504
    Location:13285
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB