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Il1rl2 interleukin 1 receptor-like 2 [ Mus musculus (house mouse) ]

Gene ID: 107527, updated on 5-Mar-2024

Summary

Official Symbol
Il1rl2provided by MGI
Official Full Name
interleukin 1 receptor-like 2provided by MGI
Primary source
MGI:MGI:1913107
See related
Ensembl:ENSMUSG00000070942 AllianceGenome:MGI:1913107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IL-1Rrp2
Summary
Predicted to enable cytokine receptor activity. Acts upstream of or within positive regulation of T cell differentiation; positive regulation of interleukin-6 production; and regulation of inflammatory response. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human IL1RL2 (interleukin 1 receptor like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 3.8), subcutaneous fat pad adult (RPKM 2.3) and 21 other tissues See more
Orthologs
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Genomic context

See Il1rl2 in Genome Data Viewer
Location:
1 B; 1 18.96 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40363697..40406722)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40324589..40367555)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35741 Neighboring gene interleukin 1 receptor, type I Neighboring gene STARR-positive B cell enhancer ABC_E5749 Neighboring gene STARR-seq mESC enhancer starr_00738 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene interleukin 1 receptor-like 1 Neighboring gene STARR-seq mESC enhancer starr_00741 Neighboring gene interleukin 18 receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (8) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
 
enables NADP+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables cytokine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-1 receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-1, type I, activating receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-1 receptor-like 2
Names
IL-36 receptor
IL1R-rp2
interleukin-1 receptor related protein 2
NP_001343407.1
NP_573456.1
XP_006495672.1
XP_006495673.1
XP_036021840.1
XP_036021873.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356478.1NP_001343407.1  interleukin-1 receptor-like 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC167168
    Consensus CDS
    CCDS14910.1
    UniProtKB/Swiss-Prot
    Q9ERS7
    UniProtKB/TrEMBL
    Q149G7
    Related
    ENSMUSP00000142248.2, ENSMUST00000194296.6
    Conserved Domains (3) summary
    pfam01582
    Location:389539
    TIR; TIR domain
    cd00096
    Location:3135
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:25115
    Ig; Immunoglobulin domain
  2. NM_133193.4NP_573456.1  interleukin-1 receptor-like 2 precursor

    See identical proteins and their annotated locations for NP_573456.1

    Status: VALIDATED

    Source sequence(s)
    AC167168
    Consensus CDS
    CCDS14910.1
    UniProtKB/Swiss-Prot
    Q9ERS7
    UniProtKB/TrEMBL
    Q149G7
    Related
    ENSMUSP00000092630.4, ENSMUST00000095020.9
    Conserved Domains (3) summary
    pfam01582
    Location:389539
    TIR; TIR domain
    cd00096
    Location:3135
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:25115
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    40363697..40406722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165947.1XP_036021840.1  interleukin-1 receptor-like 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9ERS7
    UniProtKB/TrEMBL
    Q149G7
    Conserved Domains (3) summary
    pfam01582
    Location:389539
    TIR; TIR domain
    cd00096
    Location:3135
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:25115
    Ig; Immunoglobulin domain
  2. XM_006495609.4XP_006495672.1  interleukin-1 receptor-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006495672.1

    UniProtKB/Swiss-Prot
    Q9ERS7
    UniProtKB/TrEMBL
    Q149G7
    Conserved Domains (3) summary
    pfam01582
    Location:389539
    TIR; TIR domain
    cd00096
    Location:3135
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:25115
    Ig; Immunoglobulin domain
  3. XM_006495610.5XP_006495673.1  interleukin-1 receptor-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006495673.1

    UniProtKB/Swiss-Prot
    Q9ERS7
    UniProtKB/TrEMBL
    Q149G7
    Conserved Domains (3) summary
    pfam01582
    Location:389539
    TIR; TIR domain
    cd00096
    Location:3135
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:25115
    Ig; Immunoglobulin domain
  4. XM_036165980.1XP_036021873.1  interleukin-1 receptor-like 2 isoform X2

    Conserved Domains (3) summary
    pfam01582
    Location:361511
    TIR; TIR domain
    cd00096
    Location:37
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:187
    Ig; Immunoglobulin domain