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Il1rl2 interleukin 1 receptor-like 2 [ Mus musculus (house mouse) ]

Gene ID: 107527, updated on 9-Mar-2023

Summary

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Official Symbol
Il1rl2provided by MGI
Official Full Name
interleukin 1 receptor-like 2provided by MGI
Primary source
MGI:MGI:1913107
See related
Ensembl:ENSMUSG00000070942 AllianceGenome:MGI:1913107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IL-1Rrp2
Summary
Predicted to enable cytokine receptor activity. Acts upstream of or within positive regulation of T cell differentiation; positive regulation of interleukin-6 production; and regulation of inflammatory response. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human IL1RL2 (interleukin 1 receptor like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 3.8), subcutaneous fat pad adult (RPKM 2.3) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Il1rl2 in Genome Data Viewer
Location:
1; 1 B
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40363697..40406722)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40324589..40367555)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35741 Neighboring gene interleukin 1 receptor, type I Neighboring gene ribosomal protein 10 pseudogene Neighboring gene interleukin 1 receptor-like 1 Neighboring gene interleukin 18 receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis. Goldstein JD, et al. Life Sci Alliance, 2020 Jun. PMID 32345660, Free PMC Article
  2. Knockout of the interleukin-36 receptor protects against renal ischemia-reperfusion injury by reduction of proinflammatory cytokines. Nishikawa H, et al. Kidney Int, 2018 Mar. PMID 29241623
  3. Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts. Schmitt V, et al. Eur J Immunol, 2017 Dec. PMID 28857172
  4. IL-36 receptor deletion attenuates lung injury and decreases mortality in murine influenza pneumonia. Aoyagi T, et al. Mucosal Immunol, 2017 Jul. PMID 27966554, Free PMC Article
  5. Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage. Medina-Contreras O, et al. J Immunol, 2016 Jan 1. PMID 26590314, Free PMC Article

See all (39) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent manner.
    Title: Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent manner.
  2. IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis.
    Title: IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis.
  3. IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria.
    Title: IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria.
  4. IL-36R likely contributes to acute kidney injury pathogenesis through NF-kB activity and IL-6 and TNF-a upregulation.
    Title: Knockout of the interleukin-36 receptor protects against renal ischemia-reperfusion injury by reduction of proinflammatory cytokines.
  5. these findings reveal a fundamental contribution for the IL-36/IL-36R axis in regulating the Treg-Th9 cell balance with broad implications for Th cell-mediated disorders, such as inflammatory bowel diseases and particularly ulcerative colitis
    Title: IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NFκB activation and STAT transcription factors.
  6. IL-36R-deficient mice were protected from influenza virus-induced lung injury and mortality
    Title: IL-36 receptor deletion attenuates lung injury and decreases mortality in murine influenza pneumonia.
  7. Data show that Interleukin-36 receptor (IL-36R)-deficient fibroblast-like synoviocytes (FLS) had a limited capacity to support plasma cells (PC) survival compared to wild-type FLS.
    Title: Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD(P)+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables cytokine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1, type I, activating receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
interleukin-1 receptor-like 2
Names
IL-36 receptor
IL1R-rp2
interleukin-1 receptor related protein 2
NP_001343407.1
NP_573456.1
XP_006495672.1
XP_006495673.1
XP_036021840.1
XP_036021873.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356478.1 → NP_001343407.1  interleukin-1 receptor-like 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC167168
    Consensus CDS
    CCDS14910.1
    UniProtKB/Swiss-Prot
    Q9ERS7
    UniProtKB/TrEMBL
    Q149G7
    Related
    ENSMUSP00000142248.2, ENSMUST00000194296.6
    Conserved Domains (3) summary
    pfam01582
    Location:389 → 539
    TIR; TIR domain
    cd00096
    Location:31 → 35
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:25 → 115
    Ig; Immunoglobulin domain

  2. NM_133193.4 → NP_573456.1  interleukin-1 receptor-like 2 precursor

    See identical proteins and their annotated locations for NP_573456.1

    Status: VALIDATED

    Source sequence(s)
    AC167168
    Consensus CDS
    CCDS14910.1
    UniProtKB/Swiss-Prot
    Q9ERS7
    UniProtKB/TrEMBL
    Q149G7
    Related
    ENSMUSP00000092630.4, ENSMUST00000095020.9
    Conserved Domains (3) summary
    pfam01582
    Location:389 → 539
    TIR; TIR domain
    cd00096
    Location:31 → 35
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:25 → 115
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    40363697..40406722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165947.1 → XP_036021840.1  interleukin-1 receptor-like 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9ERS7
    UniProtKB/TrEMBL
    Q149G7
    Conserved Domains (3) summary
    pfam01582
    Location:389 → 539
    TIR; TIR domain
    cd00096
    Location:31 → 35
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:25 → 115
    Ig; Immunoglobulin domain

  2. XM_006495609.4 → XP_006495672.1  interleukin-1 receptor-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006495672.1

    UniProtKB/Swiss-Prot
    Q9ERS7
    UniProtKB/TrEMBL
    Q149G7
    Conserved Domains (3) summary
    pfam01582
    Location:389 → 539
    TIR; TIR domain
    cd00096
    Location:31 → 35
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:25 → 115
    Ig; Immunoglobulin domain

  3. XM_006495610.5 → XP_006495673.1  interleukin-1 receptor-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006495673.1

    UniProtKB/Swiss-Prot
    Q9ERS7
    UniProtKB/TrEMBL
    Q149G7
    Conserved Domains (3) summary
    pfam01582
    Location:389 → 539
    TIR; TIR domain
    cd00096
    Location:31 → 35
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:25 → 115
    Ig; Immunoglobulin domain

  4. XM_036165980.1 → XP_036021873.1  interleukin-1 receptor-like 2 isoform X2

    Conserved Domains (3) summary
    pfam01582
    Location:361 → 511
    TIR; TIR domain
    cd00096
    Location:3 → 7
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:1 → 87
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERS7.1 GenPept UniProtKB/Swiss-Prot:Q9ERS7

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