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MAP3K2 mitogen-activated protein kinase kinase kinase 2 [ Homo sapiens (human) ]

Gene ID: 10746, updated on 28-Aug-2022

Summary

Official Symbol
MAP3K2provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 2provided by HGNC
Primary source
HGNC:HGNC:6854
See related
Ensembl:ENSG00000169967 MIM:609487; AllianceGenome:HGNC:6854
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEKK2; MEKK2B
Summary
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 11.2), thyroid (RPKM 10.3) and 25 other tissues See more
Orthologs
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Genomic context

See MAP3K2 in Genome Data Viewer
Location:
2q14.3
Exon count:
20
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (127298668..127388465, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (127733893..127823745, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (128056244..128146041, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene WBP11 pseudogene 2 Neighboring gene ERCC excision repair 3, TFIIH core complex helicase subunit Neighboring gene RNA, U6 small nuclear 1147, pseudogene Neighboring gene uncharacterized LOC124906074 Neighboring gene MAP3K2 divergent transcript Neighboring gene translation initiation factor IF-2-like Neighboring gene microRNA 4783 Neighboring gene protein C, inactivator of coagulation factors Va and VIIIa

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies MAP3K2, a member of mitogen-activated protein kinase kinase family (serine/threonine protein kinase), is important for HIV-1 replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 2
Names
MAP/ERK kinase kinase 2
MAPK/ERK kinase kinase 2
MEK kinase 2
MEKK 2
NP_001358839.1
NP_001358840.1
NP_006600.3
XP_047298945.1
XP_047298946.1
XP_047298947.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371910.2NP_001358839.1  mitogen-activated protein kinase kinase kinase 2

    Status: REVIEWED

    Source sequence(s)
    AC068282, AC110926
    UniProtKB/Swiss-Prot
    Q9NYK3
    UniProtKB/TrEMBL
    A0A024RAH0
    Related
    ENSP00000507315.1, ENST00000682094.1
    Conserved Domains (2) summary
    cd06405
    Location:44122
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:353616
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2
  2. NM_001371911.1NP_001358840.1  mitogen-activated protein kinase kinase kinase 2

    Status: REVIEWED

    Source sequence(s)
    AC068282, AC110926
    UniProtKB/Swiss-Prot
    Q9NYK3
    UniProtKB/TrEMBL
    A0A024RAH0
    Related
    ENSP00000387246.1, ENST00000409947.5
    Conserved Domains (2) summary
    cd06405
    Location:44122
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:353616
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2
  3. NM_006609.5NP_006600.3  mitogen-activated protein kinase kinase kinase 2

    See identical proteins and their annotated locations for NP_006600.3

    Status: REVIEWED

    Source sequence(s)
    AC068282, AC110926
    Consensus CDS
    CCDS46404.1
    UniProtKB/Swiss-Prot
    Q9NYK3, Q9Y2U5
    UniProtKB/TrEMBL
    A0A024RAH0
    Related
    ENSP00000343463.5, ENST00000344908.9
    Conserved Domains (2) summary
    cd06405
    Location:44122
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:353616
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    127298668..127388465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442990.1XP_047298946.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NYK3
    UniProtKB/TrEMBL
    A0A024RAH0
  2. XM_047442991.1XP_047298947.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NYK3
    UniProtKB/TrEMBL
    A0A024RAH0
  3. XM_047442989.1XP_047298945.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NYK3
    UniProtKB/TrEMBL
    A0A024RAH0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    127733893..127823745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)