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Unc5b unc-5 netrin receptor B [ Mus musculus (house mouse) ]

Gene ID: 107449, updated on 8-Dec-2022

Summary

Official Symbol
Unc5bprovided by MGI
Official Full Name
unc-5 netrin receptor Bprovided by MGI
Primary source
MGI:MGI:894703
See related
Ensembl:ENSMUSG00000020099 AllianceGenome:MGI:894703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Unc5h2; A630020F16; D10Bwg0792e; 6330415E02Rik
Summary
Predicted to enable netrin receptor activity. Acts upstream of or within anterior/posterior axon guidance. Predicted to be located in membrane raft. Is expressed in several structures, including brain; forelimb; ganglia; limb bud; and sensory organ. Orthologous to human UNC5B (unc-5 netrin receptor B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine adult (RPKM 21.1), colon adult (RPKM 20.9) and 23 other tissues See more
Orthologs
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Genomic context

See Unc5b in Genome Data Viewer
Location:
10 B4; 10 31.52 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (60598373..60667360, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (60762594..60831581, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene solute carrier family 29 (nucleoside transporters), member 3 Neighboring gene VISTA enhancer mm1663 Neighboring gene predicted gene, 36750 Neighboring gene microRNA 6408

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables netrin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
netrin receptor UNC5B
Names
protein unc-5 homolog 2
protein unc-5 homolog B
unc5 homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359273.1NP_001346202.1  netrin receptor UNC5B isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK018177, AK147603, AW488068, BC048162
    Consensus CDS
    CCDS88011.1
    Related
    ENSMUSP00000151251.2, ENSMUST00000218637.2
    Conserved Domains (5) summary
    smart00218
    Location:530633
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08802
    Location:847930
    Death_UNC5B; Death domain found in Uncoordinated-5B
    smart00209
    Location:249300
    TSP1; Thrombospondin type 1 repeats
    pfam17217
    Location:680819
    UPA; UPA domain
    cl11960
    Location:157243
    Ig; Immunoglobulin domain
  2. NM_029770.3NP_084046.2  netrin receptor UNC5B isoform 1 precursor

    See identical proteins and their annotated locations for NP_084046.2

    Status: VALIDATED

    Source sequence(s)
    AK018177, AK147603, AK158284, AW488068, BC048162
    Consensus CDS
    CCDS23872.1
    UniProtKB/Swiss-Prot
    Q8K1S3, Q9D398
    Related
    ENSMUSP00000077080.6, ENSMUST00000077925.7
    Conserved Domains (5) summary
    smart00218
    Location:541644
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08802
    Location:858941
    Death_UNC5B; Death domain found in Uncoordinated-5B
    smart00209
    Location:249300
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:155243
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:157243
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    60598373..60667360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)