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Unc5a unc-5 netrin receptor A [ Mus musculus (house mouse) ]

Gene ID: 107448, updated on 8-Dec-2022

Summary

Official Symbol
Unc5aprovided by MGI
Official Full Name
unc-5 netrin receptor Aprovided by MGI
Primary source
MGI:MGI:894682
See related
Ensembl:ENSMUSG00000025876 AllianceGenome:MGI:894682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Unc5h1; mKIAA1976
Summary
Predicted to enable netrin receptor activity. Acts upstream of or within anterior/posterior axon guidance. Predicted to be located in neuron projection membrane and neuronal cell body membrane. Predicted to be intrinsic component of plasma membrane. Is expressed in several structures, including brain; sensory organ; skeleton; ventral grey horn; and vibrissa follicle. Orthologous to human UNC5A (unc-5 netrin receptor A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 18.5), adrenal adult (RPKM 16.6) and 22 other tissues See more
Orthologs
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Genomic context

See Unc5a in Genome Data Viewer
Location:
13; 13 B1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55090545..55153831)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54945151..55006018)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5330429C05 gene Neighboring gene RIKEN cDNA 4930526F13 gene Neighboring gene predicted gene, 31313 Neighboring gene hexokinase 3 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene zinc finger protein 346 Neighboring gene predicted gene, 46415

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables netrin receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in anterior/posterior axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within anterior/posterior axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in axon guidance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in netrin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
netrin receptor UNC5A
Names
protein unc-5 homolog 1
protein unc-5 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311128.2NP_001298057.1  netrin receptor UNC5A isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC154610
    Consensus CDS
    CCDS79188.1
    UniProtKB/Swiss-Prot
    Q8K1S4
    Related
    ENSMUSP00000105621.3, ENSMUST00000109994.9
    Conserved Domains (5) summary
    smart00218
    Location:439542
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:245293
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151239
    I-set; Immunoglobulin I-set domain
    cd08800
    Location:755838
    Death_UNC5A; Death domain found in Uncoordinated-5A
    cl11960
    Location:153239
    Ig; Immunoglobulin domain
  2. NM_153131.5NP_694771.1  netrin receptor UNC5A isoform 1 precursor

    See identical proteins and their annotated locations for NP_694771.1

    Status: VALIDATED

    Source sequence(s)
    AC154610
    Consensus CDS
    CCDS26537.1
    UniProtKB/Swiss-Prot
    Q80T71, Q8K1S4
    Related
    ENSMUSP00000026994.8, ENSMUST00000026994.14
    Conserved Domains (5) summary
    smart00218
    Location:495598
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:245296
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151239
    I-set; Immunoglobulin I-set domain
    cd08800
    Location:811894
    Death_UNC5A; Death domain found in Uncoordinated-5A
    cl11960
    Location:153239
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55090545..55153831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517037.3XP_006517100.2  netrin receptor UNC5A isoform X1

    Conserved Domains (5) summary
    smart00218
    Location:670773
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:420471
    TSP1; Thrombospondin type 1 repeats
    cd08800
    Location:9861069
    Death_UNC5A; Death domain found in Uncoordinated-5A
    pfam17217
    Location:820959
    UPA; UPA domain
    cl11960
    Location:328414
    Ig; Immunoglobulin domain
  2. XM_006517038.3XP_006517101.2  netrin receptor UNC5A isoform X2

    Conserved Domains (5) summary
    smart00218
    Location:614717
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:420468
    TSP1; Thrombospondin type 1 repeats
    cd08800
    Location:9301013
    Death_UNC5A; Death domain found in Uncoordinated-5A
    pfam17217
    Location:764903
    UPA; UPA domain
    cl11960
    Location:328414
    Ig; Immunoglobulin domain

RNA

  1. XR_001780744.3 RNA Sequence