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PTTG2 pituitary tumor-transforming 2 [ Homo sapiens (human) ]

Gene ID: 10744, updated on 23-Nov-2021

Summary

Official Symbol
PTTG2provided by HGNC
Official Full Name
pituitary tumor-transforming 2provided by HGNC
Primary source
HGNC:HGNC:9691
See related
Ensembl:ENSG00000250254 MIM:604231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Orthologs
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Genomic context

See PTTG2 in Genome Data Viewer
Location:
4p14
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (37960398..37961128)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (37962019..37962749)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene 3 Neighboring gene TBC1 domain family member 1 Neighboring gene uncharacterized LOC105374407 Neighboring gene proteasome activator subunit 2 pseudogene 4 Neighboring gene mitochondrial ribosomal protein S33 pseudogene 2

Genomic regions, transcripts, and products

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of periodontal pathogen colonization.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
 
involved_in homologous chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of mitotic sister chromatid separation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
securin-2
Names
pituitary tumor-transforming gene 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006607.3NP_006598.2  securin-2

    See identical proteins and their annotated locations for NP_006598.2

    Status: VALIDATED

    Source sequence(s)
    AC021106, BC069114
    Consensus CDS
    CCDS54755.1
    UniProtKB/Swiss-Prot
    Q9NZH5
    Related
    ENSP00000424261.1, ENST00000504686.2
    Conserved Domains (1) summary
    pfam04856
    Location:1178
    Securin; Securin sister-chromatid separation inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    37960398..37961128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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