Format

Send to:

Choose Destination

RBBP9 RB binding protein 9, serine hydrolase [ Homo sapiens (human) ]

Gene ID: 10741, updated on 7-Jun-2020

Summary

Official Symbol
RBBP9provided by HGNC
Official Full Name
RB binding protein 9, serine hydrolaseprovided by HGNC
Primary source
HGNC:HGNC:9892
See related
Ensembl:ENSG00000089050 MIM:602908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BOG; RBBP10
Summary
The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 16.2), kidney (RPKM 8.1) and 24 other tissues See more
Orthologs

Genomic context

See RBBP9 in Genome Data Viewer
Location:
20p11.23
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (18486540..18497250, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18467184..18477899, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA polymerase III subunit F Neighboring gene microRNA 3192 Neighboring gene ribosomal protein L21 pseudogene 3 Neighboring gene ribosomal protein S19 pseudogene 1 Neighboring gene SEC23 homolog B, COPII coat complex component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9236

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
serine hydrolase RBBP9
Names
B5T overexpressed gene protein
RBBP-10
RBBP-9
putative hydrolase RBBP9
retinoblastoma-binding protein 10
retinoblastoma-binding protein 9
retinoma-binding protein 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006606.3NP_006597.2  serine hydrolase RBBP9

    See identical proteins and their annotated locations for NP_006597.2

    Status: REVIEWED

    Source sequence(s)
    AL121893
    Consensus CDS
    CCDS13136.1
    UniProtKB/Swiss-Prot
    O75884
    Related
    ENSP00000336866.4, ENST00000337227.9
    Conserved Domains (1) summary
    cl21494
    Location:8173
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    18486540..18497250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260652.2XP_005260709.1  serine hydrolase RBBP9 isoform X1

    Conserved Domains (1) summary
    pfam12695
    Location:9108
    Abhydrolase_5; Alpha/beta hydrolase family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153328.1: Suppressed sequence

    Description
    NM_153328.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Support Center