U.S. flag

An official website of the United States government


Send to:

Choose Destination

Pdzd8 PDZ domain containing 8 [ Mus musculus (house mouse) ]

Gene ID: 107368, updated on 12-Apr-2023


Official Symbol
Pdzd8provided by MGI
Official Full Name
PDZ domain containing 8provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000074746 AllianceGenome:MGI:2677270
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdzk8; A630041P07Rik
Predicted to enable lipid binding activity and metal ion binding activity. Involved in mitochondrial calcium ion homeostasis and mitochondrion-endoplasmic reticulum membrane tethering. Located in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and retina nuclear layer. Orthologous to human PDZD8 (PDZ domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in testis adult (RPKM 15.4), ovary adult (RPKM 6.8) and 28 other tissues See more
Try the new Gene table
Try the new Transcript table

Genomic context

See Pdzd8 in Genome Data Viewer
19; 19 D3
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (59284516..59334212, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (59296084..59345780, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene potassium channel, subfamily K, member 18 Neighboring gene VISTA enhancer mm447 Neighboring gene solute carrier family 18 (vesicular monoamine), member 2 Neighboring gene ribosomal protein S12, pseudogene 3 Neighboring gene predicted gene, 50440 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:59463713-59463963 Neighboring gene predicted gene, 33756 Neighboring gene VISTA enhancer mm448 Neighboring gene Emx2 opposite strand/antisense transcript (non-protein coding)

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
enables molecular_function ND
No biological Data available
more info
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
located_in membrane IEA
Inferred from Electronic Annotation
more info
is_active_in mitochondria-associated endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in mitochondria-associated endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
located_in mitochondria-associated endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info

General protein information

Preferred Names
PDZ domain-containing protein 8

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033222.3NP_001028394.2  PDZ domain-containing protein 8

    See identical proteins and their annotated locations for NP_001028394.2

    Status: VALIDATED

    Source sequence(s)
    AC139040, AK145020
    Consensus CDS
    B9EJ80, Q3UMB1
    ENSMUSP00000096880.3, ENSMUST00000099274.4
    Conserved Domains (4) summary
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    DUF4045; Domain of unknown function (DUF4045)
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000085.7 Reference GRCm39 C57BL/6J

    59284516..59334212 complement
    GenBank, FASTA, Sequence Viewer (Graphics)